氯氮平N-氧化盐酸;氯氮平N-氧化物二盐酸盐
| 中文名称 | 氯氮平N-氧化盐酸;氯氮平N-氧化物二盐酸盐 |
|---|---|
| 中文同义词 | 氯氮平N-氧化盐酸;氯氮平N-氧化物二盐酸盐;CLOZAPINE N-OXIDE DIHYDROCHLORIDE(氯氮平N-氧化盐酸);化合物 CLOZAPINE N-OXIDE DIHYDROCHLORIDE;氯氮平N-氧化物盐酸盐 |
| 英文名称 | 8-Chloro-11-(4-methyl-4-oxido-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine dihydrochloride |
| 英文同义词 | 8-Chloro-11-(4-methyl-4-oxido-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine dihydrochloride;Clozapine N-oxide dihydrochloride;Clozapine N-oxide dihydrochloride salt;Clozapine N-oxide diHCl;Clozapine N-oxide 2HCl |
| CAS号 | 2250025-93-3 |
| 分子式 | C18H21Cl3N4O- |
| 分子量 | 415.74454 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 2250025-93-3.mol |
| 结构式 |  |
氯氮平N-氧化盐酸;氯氮平N-氧化物二盐酸盐 性质
| 储存条件 | Store at 4°C,stored under nitrogen |
|---|---|
| 溶解度 | 溶于二甲基亚砜 |
| 形态 | 结晶固体 |
| 颜色 | 橙色 |
| 水溶解性 | Soluble in water (100 mM). Always store solutions at -20°C. |
Human muscarinic designer receptors (DREADDs)
Clozapine N-oxide (CNO) can bind to non-DREADD receptors at concentrations required for DREADD activation, and undergoes reverse-metabolism to its parent compound clozapine, an atypical antipsychotic that acts at a variety of pharmacological targets and produces numerous physiological and behavioral effects.
After a single intraperitoneal (i.p.) injection of Clozapine N-oxide (1 mg/kg) into mice, Clozapine N-oxide (CNO) plasma levels peak at 15 min and are very low after 2 h. Despite the short plasma half-life of CNO in mice, the biological effects that have been described after acute treatment of DREADD-expressing experimental animals are usually much longer (6-10 h).
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026/06/05 | HY-17366AR | 氯氮平N-氧化盐酸;氯氮平N-氧化物二盐酸盐 Clozapine N-oxide dihydrochloride (Standard) | 2250025-93-3 | 5 mg | 1875元 |
| 2026/06/05 | HY-17366AR | 氯氮平N-氧化盐酸;氯氮平N-氧化物二盐酸盐 Clozapine N-oxide dihydrochloride (Standard) | 2250025-93-3 | 10 mg | 3000元 |