| Company Name: |
BOC Sciences |
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16314854226; +8616314854226 |
| Email: |
inquiry@bocsci.com |
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| | CHF-5022 Basic information |
| Product Name: | CHF-5022 | | Synonyms: | CHF-5022;CHEMBL196246;UNII-JO8EVV007Q;Cyclopropanecarboxylic acid, 1-[2-fluoro-4'-(trifluoromethyl)[1,1'-biphenyl]-4-yl]- | | CAS: | 749269-77-0 | | MF: | C17H12F4O2 | | MW: | 324.27 | | EINECS: | | | Product Categories: | | | Mol File: | 749269-77-0.mol |  |
| | CHF-5022 Chemical Properties |
| Boiling point | 405.8±45.0 °C(Predicted) | | density | 1.403±0.06 g/cm3(Predicted) | | pka | 3.29±0.20(Predicted) |
| | CHF-5022 Usage And Synthesis |
| Uses | CHF5022 is an inhibitor of Aβ42 secretion (IC50=92 μM). CHF5022 retains a modest activity on Aβ40 at non-cytotoxic concentrations (22.2±4.8% at 100 μM)[1]. | | in vivo | After multiple oral administration, CHF5022 is absorbed dose-dependently, with a fair penetration of the brain (≈10%) of young Tg2575 mice[1]. | | References | [1] Imbimbo BP, et al. In vitro and in vivo profiling of CHF5022 and CHF5074 Two beta-amyloid1-42 lowering agents. Pharmacol Res. 2007 Apr;55(4):318-28. DOI:10.1016/j.phrs.2006.12.010 |
| | CHF-5022 Preparation Products And Raw materials |
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