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BMS587101 manufacturers
- BMS-587101
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- $2220.00
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2026-07-27
- CAS:509083-77-6
- Purity:
- Supply Ability: 10g
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| | BMS587101 Basic information |
| Product Name: | BMS587101 | | Synonyms: | UNII-5V7E4UQL93;BMS 587101,BMS587101;3-Thiophenecarboxylic acid, 5-[[(5S,9R)-9-(4-cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]non-7-yl]methyl]- | | CAS: | 509083-77-6 | | MF: | C26H20Cl2N4O4S | | MW: | 555.43 | | EINECS: | | | Product Categories: | | | Mol File: | 509083-77-6.mol |  |
| | BMS587101 Chemical Properties |
| Melting point | 209-230 °C | | Boiling point | 748.4±70.0 °C(Predicted) | | density | 1.60±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO : 260 mg/mL (468.11 mM; Need ultrasonic) | | pka | 3.87±0.10(Predicted) | | form | Solid | | color | Off-white to light yellow |
| | BMS587101 Usage And Synthesis |
| Uses | BMS-587101 is a potent and orally active antagonist of leukocyte function associated antigen-1 (LFA-1). BMS-587101 has anti-inflammatory effects and can be used for rheumatoid arthritis research[1][2]. | | in vivo | In the mouse ovalbumin-induced lung inflammation model, BMS-587101 (0.1 mg/kg, 1.0 mg/kg, and 10 mg/kg; po.; twice a day) treatment significantly inhibits eosinophil accumulation[1]. | | References | [1] Dominique Potin, et al. Discovery and development of 5-[(5S,9R)-9-(4-cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]non-7-yl-methyl]-3-thiophenecarboxylic acid (BMS-587101)--a small molecule antagonist of leukocyte function a DOI:10.1021/jm0610806
[2] Suzanne J Suchard, et al. An LFA-1 (alphaLbeta2) small-molecule antagonist reduces inflammation and joint destruction in murine models of arthritis. J Immunol. 2010 Apr 1;184(7):3917-26. DOI:10.4049/jimmunol.0901095 |
| | BMS587101 Preparation Products And Raw materials |
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