WITHANOLIDE B(P)(NEW) manufacturers
- Withanolide B
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- $163.00 / 1mg
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2026-04-22
- CAS:56973-41-2
- Min. Order:
- Purity:
- Supply Ability: 10g
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| | WITHANOLIDE B(P)(NEW) Basic information |
| Product Name: | WITHANOLIDE B(P)(NEW) | | Synonyms: | Withanolide B 56973-41-2;WITHANOLIDE B(SH)(NEW);(5a,6a,7a,22R)-6,7-Epoxy-5,22-dihydroxy-1-oxoergosta-2,24-dien-26-oic acid d-lactone;Lycium substance B;Withanolide B;WITHANOLIDE B(SH);(5α,6α,7α,22R)-6,7-Epoxy-5,22-dihydroxy-1-oxo-ergosta-2,24-dien-26-oic acid δ-lactone;WITHANOLIDE B(P)(NEW) | | CAS: | 56973-41-2 | | MF: | C28H38O5 | | MW: | 454.6 | | EINECS: | | | Product Categories: | | | Mol File: | 56973-41-2.mol |  |
| | WITHANOLIDE B(P)(NEW) Chemical Properties |
| density | 1.206 | | storage temp. | Store at -20°C | | solubility | Acetonitrile: 0.1 mg/ml; Methanol: 0.5 mg/ml | | form | Solid | | color | White to off-white | | InChIKey | ZTEVDTFJUUJBLP-MBMSZCMESA-N | | SMILES | C[C@H]([C@H]1CC(C)=C(C)C(=O)O1)[C@H]2CC[C@H]3[C@H]4[C@H](CC[C@]23C)[C@@]5(C)C(=O)C=CC[C@]5(O)[C@H]6O[C@@H]46 |
| WGK Germany | 3 | | Storage Class | 11 - Combustible Solids |
| | WITHANOLIDE B(P)(NEW) Usage And Synthesis |
| Uses | Withanolide B is an active component of W. somnifera Dunal. Withanolide B promotes osteogenic differentiation of hBMSCs via ERK1/2 and Wnt/β-catenin signaling pathways. Withanolide B exhibits neuroprotective, anti-arthritic, anti-aging and anti-cancer effects[1][2][3]. | | Definition | ChEBI: Withanolide B is a withanolide. | | in vivo | Withanolide B (10 mg/kg; topical administration) promotes bone healing in a rat tibial defect model[1]. | Animal Model: | Male Sprague-Dawley rats (8 weeks, 200 g) with tibial defect[1] | | Dosage: | 10 mg/kg | | Administration: | Injected in situ at the bone defect site at different time points (0, 3, 5, 7, and 9 days) | | Result: | Increased the trabecular number, trabecular thickness and the thickness of the cortical bone. |
| | References | [1] Kuang Z, et, al. Withanolide B promotes osteogenic differentiation of human bone marrow mesenchymal stem cells via ERK1/2 and Wnt/β-catenin signaling pathways. Int Immunopharmacol. 2020 Nov;88:106960. DOI:10.1016/j.intimp.2020.106960
[2] Dubey S, et, al. Improving the inhibition of β-amyloid aggregation by withanolide and withanoside derivatives. Int J Biol Macromol. 2021 Mar 15;173:56-65. DOI:10.1016/j.ijbiomac.2021.01.094
[3] Sivanandha G, et, al. Enhanced biosynthesis of withanolides by elicitation and precursor feeding in cell suspension culture of Withania somnifera (L.) Dunal in shake-flask culture and bioreactor. PLoS One. 2014 Aug 4;9(8):e104005. DOI:10.1371/journal.pone.0104005 |
| | WITHANOLIDE B(P)(NEW) Preparation Products And Raw materials |
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