| Company Name: |
Energy Chemical |
| Tel: |
400-0056266 |
| Email: |
sales8178@energy-chemical.com |
|
| | 5,5-Dibromo-2,2-dimethyl-1,3-dioxane-4,6-dione Basic information | | Uses |
| Product Name: | 5,5-Dibromo-2,2-dimethyl-1,3-dioxane-4,6-dione | | Synonyms: | 5,5-Dibromomoldrum's acid;5,5-DIBROMOMELDRUM'S ACID; >98%;Dibromomeldrum'sAcid;5,5-DIBROMOMELDRUM''S ACID (=5,5-DIBROMO-2,2-DIMETHYL-4,6-DIOXO-1,3-DIOXANE) 98+%;5,5-Dibromomeldrum's Acid (=5,5-Dibromo-2,2-dimethyl-4,6-dioxy-1,3-dioxane);5,5-Dibromo-2,2-dimethyl-4,6-dioxo-1,3-dioxane
Dibromomalonic Acid Cyclic Isopropylidine Ester
cycl-Isopropylidene Dibromomalonate;5,5-dibromo-2,2-dimethyl-1,3-Dioxane-4,6-dione;5,5-Dibromomeldrum'sAcid(=5,5-Dibromo-2,2-dimethyl-4,6-dioxy-1,3-dioxane)> | | CAS: | 66131-14-4 | | MF: | C6H6Br2O4 | | MW: | 301.92 | | EINECS: | | | Product Categories: | Bromination;Dioxanes;Dioxanes & Dioxolanes;Halogenation;Synthetic Organic Chemistry | | Mol File: | 66131-14-4.mol |  |
| | 5,5-Dibromo-2,2-dimethyl-1,3-dioxane-4,6-dione Chemical Properties |
| Melting point | 75°C | | Boiling point | 382.3±42.0 °C(Predicted) | | density | 2.052±0.06 g/cm3(Predicted) | | storage temp. | Inert atmosphere,Store in freezer, under -20°C | | solubility | almost transparency in Methanol | | form | powder to crystal | | color | White to Almost white | | InChIKey | HPBNIRVIOCWRDC-UHFFFAOYSA-N | | CAS DataBase Reference | 66131-14-4 |
| | 5,5-Dibromo-2,2-dimethyl-1,3-dioxane-4,6-dione Usage And Synthesis |
| Uses | 5,5-Dibromo-2,2-dimethyl-4,6-dione-1,3-dioxane, also known as dibromomaldomic acid, is a pharmaceutical intermediate that can be used to prepare the antifolic acid agent pemetrexed disodium. | | Reactions | Selective α-bromination of aldehydes and α′-bromination of α,β-unsaturated ketones; reductive coupling to an ethylenetetracarboxylate. | | Synthesis |
The preparative method of 5,5-Dibromo-2,2-dimethyl-1,3-dioxane-4,6-dione: by bromination of Meldrum's acid (2,2-Dimethyl-1,3-dioxane-4,6-dione) (commercially available) with Bromine in the presence of Potassium Hydroxide or Sodium Hydroxide eq 1).
| | References |
1. Bloch, R. S 1978, 140.
2. Davidson, D.; Bernhard, S. A. JACS 1948, 70, 3426.
3. Synder, H. R.; Kruse, C. W. JACS 1958, 80, 1942.
4. Novikov, V. L.; Shestak, O. P.; Kamernitskii, A. V.; Elyakov, G. B. Izv. Akad. Nauk SSSR, Ser. Khim. 1982, 476 (CA 1982, 96, 180 832).
|
| | 5,5-Dibromo-2,2-dimethyl-1,3-dioxane-4,6-dione Preparation Products And Raw materials |
|