| Company Name: |
Shanghai YuanYe Biotechnology Co., Ltd.
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| Tel: |
13636370518 |
| Email: |
shyysw007@163.com |
| Products Intro: |
Product Name:53BP1 Antibody
Purity:ExactAb?, Validated, 0.5 mg/mL Package:10μl;50μl;100μl;1ml Remarks:K10989
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| Company Name: |
Shanghai Universal Biotech Co.,Ltd
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| Tel: |
15921930842 15921930842 |
| Email: |
yh-wang@univ-bio.com |
| Products Intro: |
Product Name:53BP1 Antibody
Package:100ul Remarks: 见优宁维官网
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| Company Name: |
GeneTex, Inc.
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| Tel: |
0755-26755892 1-949-553-1900 |
| Email: |
international@genetex.com |
| Products Intro: |
Product Name:53BP1 antibody
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| Company Name: |
NSJ Bioreagents
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| Tel: |
858.663.9055 8586639055 |
| Email: |
NSJBioname@qq.com |
| Products Intro: |
Product Name:53BP1 Antibody
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| | 53BP1 antibody Chemical Properties |
| | 53BP1 antibody Usage And Synthesis |
| Source | Rabbit | | Reactivity | Human;Monkey | | Background | p53-binding protein 1 was originally identified as a p53 binding partner that could enhance the transcriptional activity of p53. 53BP1 consists of two BRCA1 carboxy terminal domains that allow for binding to p53 and a separate domain responsible for binding to phosphorylated histone H2A.X. 53BP1 rapidly translocates to nuclear foci following treatment of cells with ionizing radiation or radiomimetic agents that cause DNA double strand breaks. Because of this localization to DSBs and homology to the yeast protein Rad9, a role for 53BP1 in DSB repair has been proposed. Recruitment of 53BP1 to sites of DNA damage has been demonstrated to be independent of ATM, NBS1, and DNA-PK and retention of 53BP1 at DNA breaks requires phosphorylated H2A.X. In cells lacking 53BP1, phosphorylation of ATM substrates is reduced, suggesting that 53BP1 is upstream of ATM. In response to IR, phosphorylation of 53BP1 at serines 6, 25, 29, and 784 by ATM has been demonstrated, but phosphorylation at these sites is not required for localization of 53BP1 to sites of DSBs. Phosphorylation of 53BP1 at Ser1618 has been reported to be enriched in human cells arrested in mitosis. | | References | [1] Iwabuchi, K. et al. (1994) Proc. Natl. Acad. Sci. USA 91, 6098-12.
[2] Iwabuchi, K. et al. (1998) J. Biol. Chem. 273, 26061-8.
[3] Mochan, T.A. et al. (2004) DNA Repair (Amst) 3, 945-52.
[4] Schultz, L.B. et al. (2000) J. Cell Biol. 151, 1381-90.
[5] Anderson, L. et al. (2001) Mol. Cell. Biol. 21, 1719-29.
[6] Ward, I.M. et al. (2003) J. Biol. Chem. 278, 19579-82.
[7] DiTullio, R.A. et al. (2002) Nat. Cell Biol. 4, 998-1002.
[8] Dephoure, N. et al. (2008) Proc Natl Acad Sci U S A 105, 10762-7. |
| | 53BP1 antibody Preparation Products And Raw materials |
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