| Company Name: |
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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| Tel: |
18818260767 |
| Email: |
sales@chemegen.com |
| Products Intro: |
Product Name:PROTAC K-Ras Degrader-1
CAS:2378258-52-5
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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| Company Name: |
cjbscvictory
|
| Tel: |
13348960310 |
| Email: |
3003867561@qq.com |
| Products Intro: |
Product Name:PROTAC K-Ras Degrader-1
CAS:2378258-52-5
Purity:98% Package:5mg；10mg；20mg；50mg；100mg；200mg
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| | PROTAC K-Ras Degrader-1 Basic information |
| Product Name: | PROTAC K-Ras Degrader-1 | | Synonyms: | PROTAC K-Ras Degrader-1;K-Ras Degrader-1;2-Piperazineacetonitrile, 4-[2-[[(2S,4R)-4-[2-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethoxy]ethoxy]-1-methyl-2-pyrrolidinyl]methoxy]-5,6,7,8-tetrahydro-7-(1-naphthalenyl)pyrido[3,4-d]pyrimidin-4-yl]-1-(1-oxo-2-propen-1-yl)-, (2S)- | | CAS: | 2378258-52-5 | | MF: | C53H62N10O10 | | MW: | 999.14 | | EINECS: | | | Product Categories: | | | Mol File: | 2378258-52-5.mol |  |
| | PROTAC K-Ras Degrader-1 Chemical Properties |
| density | 1.40±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO: 33.33 mg/mL (33.36 mM) | | form | Solid | | pka | 10.74±0.40(Predicted) | | color | Light yellow to yellow |
| | PROTAC K-Ras Degrader-1 Usage And Synthesis |
| Description | PROTAC K-Ras Degrader-1 (Compound 518) is potent K-Ras degrader based PROTAC, exhibits ≥70% degradation efficacy in SW1573 cells[1]. | | Uses | PROTAC K-Ras Degrader-1 (Compound 518) is a PROTAC. PROTAC K-Ras Degrader-1 can effectively degrades K-Ras based on Cereblon E3 ligand, exhibits ≥70% degradation efficacy in SW1573 cells[1]. | | IC 50 | KRAS(G12C); Cereblon | | References | [1]. CREW, Andrew P., et al. MODULATORS OF PROTEOLYSIS AND ASSOCIATED METHODS OF USE. WO2019195609A2. |
| | PROTAC K-Ras Degrader-1 Preparation Products And Raw materials |
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