6-amino-4-methoxy analogue of ZSTK474 (Compound 10w)

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6-amino-4-methoxy analogue of ZSTK474 (Compound 10w) manufacturers

  • PI3K-IN-54
  • PI3K-IN-54 pictures
  • $57.00
  • 2026-06-12
  • CAS:1336890-05-1
  • Purity: 98.15%
  • Supply Ability: 10g
6-amino-4-methoxy analogue of ZSTK474 (Compound 10w) Basic information
Product Name:6-amino-4-methoxy analogue of ZSTK474 (Compound 10w)
Synonyms:6-amino-4-methoxy analogue of ZSTK474 (Compound 10w);1H-Benzimidazol-6-amine, 2-(difluoromethyl)-1-(4,6-di-4-morpholinyl-1,3,5-triazin-2-yl)-4-methoxy-;Compound 10w
CAS:1336890-05-1
MF:C20H24F2N8O3
MW:462.45
EINECS:
Product Categories:
Mol File:1336890-05-1.mol
6-amino-4-methoxy analogue of ZSTK474 (Compound 10w) Structure
6-amino-4-methoxy analogue of ZSTK474 (Compound 10w) Chemical Properties
storage temp. Store at -20°C
solubility DMSO: 46 mg/mL (99.47 mM);Ethanol: Insoluble
Water Solubility Water: Insoluble
Safety Information
MSDS Information
6-amino-4-methoxy analogue of ZSTK474 (Compound 10w) Usage And Synthesis
UsesPI3K-IN-54 (compound 10w) is a pan-PI3K inhibitor. The IC50 values of PI3K-IN-54 for p110α, p110β, and p110δ are 0.22 nM, 1.4 nM, and 0.38 nM, respectively. PI3K-IN-54 can be used in cancer research[1].
Biological ActivityCompound 10w, a substituted pyrazolo [1,5-a] pyrimidine amide derivative, shows good anticancer activity against HeLa cell line, with IC50 of less than 10 μM against HeLa cell.
IC 50p110α: 0.22 nM (IC50); p110β: 1.4 nM (IC50); p110δ: 0.38 nM (IC50)
References[1] Kumar AKA, et al. Medicinal Chemistry Research. 2017; 26, 714-744.
6-amino-4-methoxy analogue of ZSTK474 (Compound 10w) Preparation Products And Raw materials
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