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GeneTex, Inc. |
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Enzo Biochem Inc |
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Biosynth Ltd |
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| Product Name: | CaMKII Antibody | | Synonyms: | CaMKII Antibody;CaMKII-γ Antibody;Rabbit Monoclonal CaMKII Antibody | | CAS: | | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![CaMKII Antibody Structure]() |
| | CaMKII Antibody Chemical Properties |
| | CaMKII Antibody Usage And Synthesis |
| Source | Rabbit | | Reactivity | Human;Mouse;Rat | | Background | CaMKII is an important member of the calcium/calmodulin-activated protein kinase family, functioning in neural synaptic stimulation and T cell receptor signaling. CaMKII has catalytic and regulatory domains. Ca2+/calmodulin binding to the CaMKII regulatory domain relieves autoinhibition and activates the kinase. The activated CaMKII further autophosphorylates at Thr286 to render the kinase constitutively active. The threonine phosphorylation state of CaMKII can be regulated through PP1/PKA. PP1 dephosphorylates phospho-CaMKII at Thr286. PKA prevents phospho-CaMKII dephosphorylation through an inhibitory effect on PP1. | | References | [1] Hughes, K. et al. (2001) J Biol Chem 276, 36008-13.
[2] Barria, A. et al. (1997) Science 276, 2042-5.
[3] Barkai, U. et al. (2000) Mol Endocrinol 14, 554-63.
[4] Makhinson, M. et al. (1999) J Neurosci 19, 2500-10. |
| | CaMKII Antibody Preparation Products And Raw materials |
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