|
|
| | GCKR (D1W9P) Rabbit mAb Chemical Properties |
| | GCKR (D1W9P) Rabbit mAb Usage And Synthesis |
| Source | Rabbit | | Reactivity | Human;Mouse;Rat | | Background | Glucokinase regulatory protein regulates the activity and localization of glucokinase, an important metabolic regulator of glucose uptake, glycogen synthesis, and glucose production in hepatocytes. GKRP plays a key role in glucose homeostasis as it inhibits glucokinase activity and sequesters this metabolic enzyme in hepatocyte nuclei; in response to changes in glucose concentration, GCKR promotes the release of glucokinase into the cytoplasm. During conditions of low blood glucose levels, GCKR binds to fructose-6-phosphate, which leads to GCKR binding to glucokinase and the subsequent nuclear localization and inactivation of glucokinase. After feeding, GCKR binds fructose-1-phosphate, which disrupts the interaction between GCKR and glucokinase and releases active glucokinase to cytoplasm. Polymorphisms in the corresponding GCKR gene are associated with atypical plasma triglyceride levels, fasting glucose and insulin levels, and glucokinase activity. | | References | [1] Printz, R.L. et al. (1993) Annu Rev Nutr 13, 463-96.
[2] Choi, J.M. et al. (2013) Proc Natl Acad Sci U S A 110, 10171-6.
[3] Iynedjian, P.B. (2009) Cell Mol Life Sci 66, 27-42.
[4] Orho-Melander, M. et al. (2008) Diabetes 57, 3112-21.
[5] Beer, N.L. et al. (2009) Hum Mol Genet 18, 4081-8. |
| | GCKR (D1W9P) Rabbit mAb Preparation Products And Raw materials |
|