| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:Phortress free base
CAS:741241-36-1
Package:1removed
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Phortress free base manufacturers
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| | Phortress free base Basic information |
| Product Name: | Phortress free base | | Synonyms: | Phortress free base;Hexanamide, 2,6-diamino-N-[4-(5-fluoro-2-benzothiazolyl)-2-methylphenyl]-, (2S)-;(2S)-2,6-diamino-N-[4-(5-fluoro-1,3-benzothiazol-2-yl)-2-methyl-phenyl]hexanamide | | CAS: | 741241-36-1 | | MF: | C20H23FN4OS | | MW: | 386.49 | | EINECS: | | | Product Categories: | | | Mol File: | 741241-36-1.mol |  |
| | Phortress free base Chemical Properties |
| density | 1.293±0.06 g/cm3(Predicted) | | pka | 13.36±0.70(Predicted) |
| | Phortress free base Usage And Synthesis |
| Uses | Phortress free base (NSC 710305) is a P450 CYP1A1-activated antitumor prodrug with antitumor activity[1]. Phortress free base leads to DNA damage and cell cycle arrest[2]. | | IC 50 | CYP1 | | References | [1] Behrsing HP, et al. In vitro exposure of precision-cut lung slices to 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole lysylamide dihydrochloride (NSC 710305, Phortress) increases inflammatory cytokine content and tissue damage. Toxicol Sci. 2013 Feb;131(2):470-9. DOI:10.1093/toxsci/kfs319
[2] Trapani V, et al. DNA damage and cell cycle arrest induced by 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole (5F 203, NSC 703786) is attenuated in aryl hydrocarbon receptor deficient MCF-7 cells. Br J Cancer. 2003 Feb 24;88(4):599-605. DOI:10.1038/sj.bjc.6600722 |
| | Phortress free base Preparation Products And Raw materials |
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