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| | FAK ligand-Linker Conjugate 1 Basic information |
| Product Name: | FAK ligand-Linker Conjugate 1 | | Synonyms: | FAK ligand-Linker Conjugate 1;Propanoic acid, 3-[2-[4-[[4-[[[3-[methyl(methylsulfonyl)amino]phenyl]methyl]amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]phenoxy]ethoxy]-;3-(2-(4-((4-((3-(N-Methylmethylsulfonamido)benzyl)amino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenoxy)ethoxy)propanoic acid;3-[2-(4-{[4-({[3-(N-methylmethanesulfonamido)phenyl]methyl}amino)-5-(trifluoromethyl)pyrimidin-2-yl]amino}phenoxy)ethoxy]propanoic acid | | CAS: | 2307461-45-4 | | MF: | C25H28F3N5O6S | | MW: | 583.58 | | EINECS: | | | Product Categories: | | | Mol File: | 2307461-45-4.mol |  |
| | FAK ligand-Linker Conjugate 1 Chemical Properties |
| form | Solid | | color | White to off-white |
| | FAK ligand-Linker Conjugate 1 Usage And Synthesis |
| Uses | FAK ligand-Linker Conjugate 1 incorporates a ligand for FAK, and a PROTAC linker, which recruit E3 ligases (such as VHL, CRBN, MDM2, and IAP). FAK ligand-Linker Conjugate 1 can be extensively used for PROTAC-mediated protein degradation[1]. | | References | [1] Cromm PM, et al. Addressing Kinase-Independent Functions of Fak via PROTAC-Mediated Degradation. J Am Chem Soc. 2018 Dec 12;140(49):17019-17026. DOI:10.1021/jacs.8b08008 |
| | FAK ligand-Linker Conjugate 1 Preparation Products And Raw materials |
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