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| | MI-1481 Basic information |
| Product Name: | MI-1481 | | Synonyms: | MI-1481;1H-Indole-2-carbonitrile, 4-methyl-1-[[(2S)-5-oxo-2-morpholinyl]methyl]-5-[[4-[[6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino]-1-piperidinyl]methyl]- | | CAS: | 1887178-64-4 | | MF: | C29H30F3N7O2S | | MW: | 597.65 | | EINECS: | | | Product Categories: | | | Mol File: | 1887178-64-4.mol |  |
| | MI-1481 Chemical Properties |
| Boiling point | 813.9±65.0 °C(Predicted) | | density | 1.50±0.1 g/cm3(Predicted) | | pka | 14.06±0.40(Predicted) |
| | MI-1481 Usage And Synthesis |
| Uses | MI-1481 is a highly potent inhibitor of the Menin-MLL1 interaction with IC50 of 3.6 nM. MI-1481 markedly reduces cell growth of murine bone marrow cells transformed and inhibits leukemia progression[1]. | | References | [1] Borkin D, et.al. Complexity of Blocking Bivalent Protein-Protein Interactions: Development of a Highly Potent Inhibitor of the Menin-Mixed-Lineage Leukemia Interaction. J Med Chem. 2018 Jun 14;61(11):4832-4850. DOI:10.1021/acs.jmedchem.8b00071 |
| | MI-1481 Preparation Products And Raw materials |
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