| Company Name: |
Shanghai Yifei Biotechnology Co. , Ltd.
|
| Tel: |
021-65675885 18964387627 |
| Email: |
customer_service@efebio.com |
| Products Intro: |
Product Name:NSC-689857
CAS:241127-79-7
Purity:95.00% Package:2mg;5mg;25mg
|
| Company Name: |
TargetMol Chemicals Inc.
|
| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:NSC-689857
CAS:241127-79-7
Package:2mg/RMB 1210;5mg/RMB 2100;25mg/RMB 7190
|
Benzoic acid, 4-[[(2,5-dihydroxyphenyl)methyl]amino]-, tricyclo[3.3.1.13,7]dec-1-ylmethyl ester manufacturers
- NSC-689857
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- $713.00 / 25mg
-
2025-08-21
- CAS:241127-79-7
- Min. Order:
- Purity:
- Supply Ability: 10g
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| | Benzoic acid, 4-[[(2,5-dihydroxyphenyl)methyl]amino]-, tricyclo[3.3.1.13,7]dec-1-ylmethyl ester Basic information |
| | Benzoic acid, 4-[[(2,5-dihydroxyphenyl)methyl]amino]-, tricyclo[3.3.1.13,7]dec-1-ylmethyl ester Chemical Properties |
| form | Solid | | color | White to off-white |
| | Benzoic acid, 4-[[(2,5-dihydroxyphenyl)methyl]amino]-, tricyclo[3.3.1.13,7]dec-1-ylmethyl ester Usage And Synthesis |
| Description | NSC-689857 is an inhibitor of the Skp2-Cks1 protein-protein interaction and p27Kip1 ubiquitination in vitro. | | Uses | NSC689857 is a potent EGFR and SCFSKP2 inhibitor with an IC50 value of 36 μM for Skp2-Cks1. NSC689857 can inhibit p27 ubiquitylation (IC50=30 μM). NSC689857 has varied activity across cancer types, with more activity against leukemia cell lines than others[1][2]. | | References | [1] Vuong W, et al. High-Throughput Screen for Inhibitors of Androgen Receptor-RUNX2 Transcriptional Regulation in Prostate Cancer. J Pharmacol Exp Ther. 2016 Nov;359(2):256-261. DOI:10.1124/jpet.116.234567
[2] Lough L, et al. Chemical probes of Skp2-mediated p27 ubiquitylation and degradation. Medchemcomm. 2018 Jun 11;9(7):1093-1104. DOI:10.1039/c8md00140e |
| | Benzoic acid, 4-[[(2,5-dihydroxyphenyl)methyl]amino]-, tricyclo[3.3.1.13,7]dec-1-ylmethyl ester Preparation Products And Raw materials |
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