N-3-oxo-pentanoyl-L-Homoserine lactone manufacturers
|
| | N-3-oxo-pentanoyl-L-Homoserine lactone Basic information |
| | N-3-oxo-pentanoyl-L-Homoserine lactone Chemical Properties |
| Boiling point | 483.2±45.0 °C(Predicted) | | density | 1.20±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMF: 20 mg/ml,DMSO: 20 mg/ml,Ethanol: 10 mg/ml | | form | A crystalline solid | | pka | 11.12±0.46(Predicted) |
| | N-3-oxo-pentanoyl-L-Homoserine lactone Usage And Synthesis |
| Uses | N-(3-Oxopentanoyl)-L-homoserine lactone is an autoinducer, a kind of chemical signal molecule which passively diffuses across the bacterial envelope and accumulates intracellularly at high bacterial densities. It may bind to a protein related to the LuxR protein of V. fischeri and causes cell density-dependent gene expression. N-(3-Oxopentanoyl)-L-homoserine can be used for research of quorum sensing[1]. | | Biological Activity | N-3-oxo-pentanoyl-L-Homoserine lactone is a chain-shortened derivative of the bacterial quorum sensing signaling molecule N-3-oxo-octanoyl-L-homoserine lactone .1 It inhibits binding of the autoinducer N-3-oxo-hexanoyl homoserine lactone to E. coli containing the transcription factor LuxR when used at a concentration of 230 nM.2 It acts as an autoinducer to activate the V. fischeri luminescence system in E. coli when used at concentrations ranging from 20 to 200 nM. | | References | 1.Chhabra, S.R., Stead, P., Bainton, N.J., et al.Autoregulation of carbapenem biosynthesis in Erwinia carotovora by analogues of N-(3-oxohexanoyl)-L-homoserine lactoneJ. Antibiot. (Tokyo)46(3)441-454(1993)
2.Schaefer, A.L., Hanzelka, B.L., Eberhard, A., et al.Quorum sensing in Vibrio fischeri: Probing autoinducer-LuxR interactions with autoinducer analogsJ. Bacteriol.178(10)2897-2901(1996) |
| | N-3-oxo-pentanoyl-L-Homoserine lactone Preparation Products And Raw materials |
|