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3-Methyl-1-[2-(trifluoromethyl)phenyl]-1H-pyrazol-5-amine manufacturers
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| | 3-Methyl-1-[2-(trifluoromethyl)phenyl]-1H-pyrazol-5-amine Basic information |
| Product Name: | 3-Methyl-1-[2-(trifluoromethyl)phenyl]-1H-pyrazol-5-amine | | Synonyms: | 5-METHYL-2-(2-TRIFLUOROMETHYL-PHENYL)-2H-PYRAZOL-3-YLAMINE;AKOS BBS-00006677;5-Amino-3-methyl-1-[2-(trifluoromethyl)phenyl]-1H-pyrazole, 2-(5-Amino-3-methyl-1H-pyrazol-1-yl)benzotrifluoride;1H-Pyrazol-5-amine, 3-methyl-1-[2-(trifluoromethyl)phenyl]-;5-Methyl-2-[2-(trifluoromethyl)phenyl]pyrazol-3-amine;3-Methyl-1-[2-(trifluoromethyl)phenyl]-1H-pyrazol-5-amine | | CAS: | 380238-10-8 | | MF: | C11H10F3N3 | | MW: | 241.21 | | EINECS: | 200-258-5 | | Product Categories: | | | Mol File: | Mol File | ![3-Methyl-1-[2-(trifluoromethyl)phenyl]-1H-pyrazol-5-amine Structure](StructureFile/ChemBookStructure5/GIF/CB1667679.gif) |
| | 3-Methyl-1-[2-(trifluoromethyl)phenyl]-1H-pyrazol-5-amine Chemical Properties |
| Boiling point | 342.7±42.0 °C(Predicted) | | density | 1.35±0.1 g/cm3(Predicted) | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | pka | 3.37±0.10(Predicted) | | form | powder | | color | Off-white |
| | 3-Methyl-1-[2-(trifluoromethyl)phenyl]-1H-pyrazol-5-amine Usage And Synthesis |
| Synthesis | GENERAL METHOD: 3-Aminobut-2-enenenitrile (10 mmol) was added to a suspension of (2-(trifluoromethyl)phenyl)hydrazine (10 mmol) in 12 M HCl-H2O (12 mL, 1:3 v/v). The reaction mixture was heated to reflux for 12 h, subsequently cooled to room temperature and neutralized with 2.5 M NaOH solution. The reaction mixture was extracted with dichloromethane (3 x 30 mL). The organic phases were combined, washed with saturated saline (20 mL), dried over anhydrous sodium sulfate and concentrated under reduced pressure. The residue was ground with hexane to give a solid product, which was separated by filtration. If necessary, the product was purified by column chromatography. | | References | [1] Bioorganic and Medicinal Chemistry, 2012, vol. 20, # 11, p. 3429 - 3445
[2] Patent: WO2010/20363, 2010, A1. Location in patent: Page/Page column 136-137
[3] Journal of Combinatorial Chemistry, 2010, vol. 12, # 4, p. 510 - 517 |
| | 3-Methyl-1-[2-(trifluoromethyl)phenyl]-1H-pyrazol-5-amine Preparation Products And Raw materials |
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