2-[(4-Nitrophenyl)amino]ethanol

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2-[(4-Nitrophenyl)amino]ethanol Basic information
Product Name:2-[(4-Nitrophenyl)amino]ethanol
Synonyms:TIMTEC-BB SBB006779;2-(4-nitroanilino)ethanol;Ethanol, 2-[(4-nitrophenyl)amino]-;2-[(4-Nitrophenyl)amino]ethanol
CAS:1965-54-4
MF:C8H10N2O3
MW:182.18
EINECS:
Product Categories:
Mol File:1965-54-4.mol
2-[(4-Nitrophenyl)amino]ethanol Structure
2-[(4-Nitrophenyl)amino]ethanol Chemical Properties
Melting point 111-111.5 °C
Boiling point 389.5±22.0 °C(Predicted)
density 1.352±0.06 g/cm3(Predicted)
form solid
pka14.57±0.10(Predicted)
color Yellow
Safety Information
HS Code 2906290090
MSDS Information
2-[(4-Nitrophenyl)amino]ethanol Usage And Synthesis
Uses2-[(4-nitrophenyl)amino]ethanol is used to prepare phenylpurinediamine derivatives as a class of reversible kinase inhibitors targeting both EGFR-activating and resistance mutations of lung cancer. It is also used to synthesize benzannulated N-heterocycles via palladium-catalyzed domino intermolecular alkylation/intramolecular amination of functionalized aryl iodides and bromoalkylamines.
Synthesis Reference(s)Synthesis, p. 606, 1976 DOI: 10.1055/s-1976-24135
2-[(4-Nitrophenyl)amino]ethanol Preparation Products And Raw materials
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