2-METHOXY-5-NITROBENZALDEHYDE manufacturers
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| | 2-METHOXY-5-NITROBENZALDEHYDE Basic information |
| | 2-METHOXY-5-NITROBENZALDEHYDE Chemical Properties |
| Melting point | 89-92 °C (lit.) | | Boiling point | 336.7±27.0 °C(Predicted) | | density | 1.322±0.06 g/cm3(Predicted) | | storage temp. | Inert atmosphere,Room Temperature | | solubility | very soluble in Dimethylformamide | | form | powder to crystal | | color | White to Light yellow to Light orange | | InChI | 1S/C8H7NO4/c1-13-8-3-2-7(9(11)12)4-6(8)5-10/h2-5H,1H3 | | InChIKey | YWVSKFXYEWMHEO-UHFFFAOYSA-N | | SMILES | COc1ccc(cc1C=O)[N+]([O-])=O | | CAS DataBase Reference | 25016-02-8 | | EPA Substance Registry System | Benzaldehyde, 2-methoxy-5-nitro- (25016-02-8) |
| WGK Germany | 3 | | TSCA | TSCA listed | | HS Code | 2913000090 | | Storage Class | 13 - Non Combustible Solids |
| | 2-METHOXY-5-NITROBENZALDEHYDE Usage And Synthesis |
| Synthesis | General procedure for the synthesis of 2-methoxy-5-nitrobenzaldehyde from 5-nitrosalicylaldehyde and iodomethane: Sodium hydride (NaH, 246 mg) and iodomethane (2.56 g) were added to a solution of 5-nitrosalicylaldehyde (1.00 g, 6.0 mmol) in N,N-dimethylformamide (DMF, 20 ml). The reaction mixture was stirred at 0°C for 8.5 hours. After completion of the reaction, the reaction mixture was extracted with ether and the organic phase was washed sequentially with aqueous sodium bicarbonate, saturated brine and 5% hydrochloric acid/saturated brine. The organic phase was dried with anhydrous magnesium sulfate and concentrated under reduced pressure to give 2-methoxy-5-nitrobenzaldehyde (0.95 g, 87.8% yield) as yellow needle-like crystals. The product was characterized by 1H NMR (CDCl3): δ 10.45 (s, 1H), 8.70 (d, J = 2.9Hz, 1H), 8.45 (dd, J = 8.8, 2.9Hz, 1H), 7.14 (d, J = 8.8Hz, 1H), 4.08 (s, 3H). | | References | [1] Angewandte Chemie - International Edition, 2011, vol. 50, # 15, p. 3435 - 3438
[2] Patent: US2013/261295, 2013, A1. Location in patent: Paragraph 0166; 0167
[3] Journal of the American Chemical Society, 2017, vol. 139, # 19, p. 6654 - 6662
[4] Patent: US5837711, 1998, A
[5] Journal of the Chemical Society, 1951, p. 2462,2466 |
| | 2-METHOXY-5-NITROBENZALDEHYDE Preparation Products And Raw materials |
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