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| | 2-AMINO-4,6-DIFLUOROBENZOIC ACID Basic information | | Uses |
| Product Name: | 2-AMINO-4,6-DIFLUOROBENZOIC ACID | | Synonyms: | 2-AMINO-4,6-DIFLUOROBENZOIC ACID;BUTTPARK 49\07-42;2-Amino-4,6-difluorobenzoic acid ,97%;2-Carboxy-3,5-difluoroaniline, 4,6-Difluoroanthranilic acid;2-AMino-4,6-difluorobenzoic acid 97%;Benzoic acid, 2-aMino-4,6-difluoro-;2-AMino-4,6-difluorobenzoic acid, 6-difluorobenzoic acid;2-Amino-4,6-difluorobenzoic acid, 95% | | CAS: | 126674-77-9 | | MF: | C7H5F2NO2 | | MW: | 173.12 | | EINECS: | | | Product Categories: | | | Mol File: | 126674-77-9.mol |  |
| | 2-AMINO-4,6-DIFLUOROBENZOIC ACID Chemical Properties |
| Boiling point | 305.8±42.0 °C(Predicted) | | density | 1.536 | | storage temp. | RT, protect from light | | form | wooly crystalline powder | | pka | 3.95±0.10(Predicted) | | color | Light yellow/gold | | Sensitive | Air Sensitive |
| Hazard Codes | Xi | | HS Code | 2916310000 |
| | 2-AMINO-4,6-DIFLUOROBENZOIC ACID Usage And Synthesis |
| Uses | 2-Amino-4,6-difluorobenzoic acid is an important pharmaceutical and pesticide intermediate, and it can also be used in liquid crystal materials. It has the advantages of high value and good market prospects. | | Synthesis | Stage 3: Synthesis of 2-amino-4,6-difluorobenzoic acid
A solution of sodium hydroxide (6.70 g, 167 mmol) and 30% hydrogen peroxide (6.7 mL) in water (60 mL) was added dropwise to a suspension of the stage 2 product (4.58 g, 25 mmol) in water (125 mL) and the reaction was carried out at 0 °C. Subsequently, the reaction mixture was stirred at room temperature for 20 hours. Upon completion of the reaction, the pH was adjusted to 3 with formic acid (~11 mL, taking care to control the rate of addition to prevent violent foaming), at which point the target compound began to precipitate. The precipitate was collected by filtration and dried in a desiccator using phosphorus pentoxide to give 3.72 g of white solid product (86% yield). The melting point of the product was 198-202 °C. | | References | [1] Patent: US2008/293749, 2008, A1. Location in patent: Page/Page column 14
[2] Journal of Medicinal Chemistry, 2006, vol. 49, # 22, p. 6465 - 6488
[3] Organic Process Research and Development, 2010, vol. 14, # 5, p. 1078 - 1087 |
| | 2-AMINO-4,6-DIFLUOROBENZOIC ACID Preparation Products And Raw materials |
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