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| | 2,5-Dichlorobenzaldehyde Basic information |
| Product Name: | 2,5-Dichlorobenzaldehyde | | Synonyms: | TIMTEC-BB SBB003793;2,5-DICHLOROBENZALDEHDYE;2,5-DICHLOROBENZALDEHYDE;2,5-Dichlorobenzaldehyde,98%;2,5-Dichlorobenzalde;2,5- twochlorobenzeneforMaldehyde;Benzaldehyde, 2,5-dichloro-;2,5-Dichlorobenzaldehyde 98% | | CAS: | 6361-23-5 | | MF: | C7H4Cl2O | | MW: | 175.01 | | EINECS: | 228-832-1 | | Product Categories: | Aromatic Aldehydes & Derivatives (substituted);Aldehydes;Phenyls & Phenyl-Het;Benzaldehyde;Phenyls & Phenyl-Het;C7;Carbonyl Compounds;bc0001 | | Mol File: | 6361-23-5.mol |  |
| | 2,5-Dichlorobenzaldehyde Chemical Properties |
| Melting point | 54-57 °C (lit.) | | Boiling point | 231-233 °C | | density | 1.3456 (rough estimate) | | refractive index | 1.5756 (estimate) | | Fp | >230 °F | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | form | Crystalline Powder | | color | White to off-white | | Sensitive | Air Sensitive | | BRN | 1635476 | | InChI | InChI=1S/C7H4Cl2O/c8-6-1-2-7(9)5(3-6)4-10/h1-4H | | InChIKey | BUXHYMZMVMNDMG-UHFFFAOYSA-N | | SMILES | C(=O)C1=CC(Cl)=CC=C1Cl | | CAS DataBase Reference | 6361-23-5(CAS DataBase Reference) |
| Hazard Codes | Xi,C | | Risk Statements | 36/37/38 | | Safety Statements | 26-36-37/39 | | RIDADR | 1759 | | WGK Germany | 3 | | Hazard Note | Corrosive | | HazardClass | 8 | | PackingGroup | III | | HS Code | 29130000 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| | 2,5-Dichlorobenzaldehyde Usage And Synthesis |
| Chemical Properties | white to off-white crystalline powder | | Synthesis Reference(s) | Journal of Medicinal Chemistry, 23, p. 506, 1980 DOI: 10.1021/jm00179a007 | | Synthesis | General procedure for the synthesis of 2,5-dichlorobenzaldehyde from 2,5-dichlorobenzenemethanol: 2,5-dichlorobenzenemethanol (1 mmol), water (1 mL), and CoFe2O4 magnetic nanoparticles (11.8 mg, 5 mol%) were added to a round bottom flask. The reaction mixture was stirred for 2 min and then Oxone (0.6 mmol) was added in three batches. The reaction mixture was stirred at room temperature for the indicated time (refer to Table 5). The progress of the reaction was monitored by thin layer chromatography (TLC, unfolding agent ethyl acetate-cyclohexane, 2:10, v/v). After completion of the reaction, the product was extracted with dichloromethane. The solvent was removed by distillation under reduced pressure to obtain the crude product. The crude product was purified using silica gel column chromatography to obtain pure 2,5-dichlorobenzaldehyde. Finally, the aliphatic by-products in dichloromethane were dried with anhydrous magnesium sulfate and analyzed by gas chromatography-flame ionization detector (GC-FID). | | References | [1] Collection of Czechoslovak Chemical Communications, 1982, vol. 47, # 11, p. 3077 - 3093
[2] Applied Organometallic Chemistry, 2018, vol. 32, # 1,
[3] Bulletin of the Korean Chemical Society, 2014, vol. 35, # 7, p. 2029 - 2032
[4] Patent: EP1661877, 2006, A1. Location in patent: Page/Page column 18
[5] Journal of Medicinal Chemistry, 1980, vol. 23, # 5, p. 506 - 511 |
| | 2,5-Dichlorobenzaldehyde Preparation Products And Raw materials |
| Raw materials | 2,5-DICHLOROBENZYL ALCOHOL-->2,5-DICHLOROBENZYL CHLORIDE-->5-Chloro-2-hydroxy-2,4,6-cycloheptatrien-1-one-->2,4,6-Cycloheptatrien-1-one, 2,5-dichloro--->Benzaldehyde-->2-Chlorotoluene-->2,5-DICHLOROTOLUENE-->Toluene-->1,4-Dichlorobenzene-->3-Chlorobenzaldehyde | | Preparation Products | 5-CHLORO-2-HYDROXYBENZYL ALCOHOL-->6-CARBOXY-X-RHODAMINE-->N-[4-[(2,5-Dichlorophenyl)[4-[N-ethyl-N-(3-sodiosulfobenzyl)amino]phenyl]methylene]-2,5-cyclohexadien-1-ylidene]-N-ethyl-3-sulfonatobenzenemethanaminium |
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