Isoxazole-5-carboxylic acid

Isoxazole-5-carboxylic acid Suppliers list

Company Name:	Anhui CONO Fine Chemical Co., Ltd. Gold
Tel:	0550-0550-7097550 15051613561
Email:	sales@ahknchem.com

Company Name:	PharmaBlock Sciences (Nanjing),Inc.
Tel:	025-86918202 4000255188
Email:	sales@pharmablock.com

Isoxazole-5-carboxylic acid manufacturers

Isoxazole-5-carboxylic acid Basic information

Product Name:	Isoxazole-5-carboxylic acid
Synonyms:	TIMTEC-BB SBB004319;AKOS PAO-1371;BUTTPARK 27\08-41;5-Isoxazolecarboxylic acid;Isoxazole-5-carboxylic acid 98%;Isoxazole-5-carboxylic acid ,98%;5-Carboxyisoxazole, 1,2-Oxazole-5-carboxylic acid, 5-Carboxy-1,2-oxazole;1,2-oxazole-5-carboxylic acid
CAS:	21169-71-1
MF:	C4H3NO3
MW:	113.07
EINECS:
Product Categories:	carboxylic acid;Oxazole&Isoxazole;Building Blocks;Heterocyclic Building Blocks;Isoxazoles
Mol File:	21169-71-1.mol

Isoxazole-5-carboxylic acid Chemical Properties

Melting point	144-148 °C(lit.)
Boiling point	211.74°C (rough estimate)
density	1.5808 (rough estimate)
refractive index	1.4543 (estimate)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
form	Powder
pka	2.29±0.10(Predicted)
color	Slightly yellow
Water Solubility	Slightly soluble in water.
Sensitive	Moisture Sensitive
InChI	InChI=1S/C4H3NO3/c6-4(7)3-1-2-5-8-3/h1-2H,(H,6,7)
InChIKey	MIIQJAUWHSUTIT-UHFFFAOYSA-N
SMILES	O1C(C(O)=O)=CC=N1
CAS DataBase Reference	21169-71-1(CAS DataBase Reference)

Safety Information

MSDS Information

Isoxazole-5-carboxylic acid Usage And Synthesis

Chemical Properties	slightly yellow powder
Uses	Reaction conditions were found to allow the exclusive formation of isoxazole-5-carboxylic acid derivatives by conjugate addition, in acidic medium, of hydroxylamine to β-alkoxyvinyl trichloromethyl ketone in synthesis and reactivity of isoxazoles. Isoxazole-5-carboxylic acid participates in the Synthesis and evaluation of acylguanidine FXa inhibitors. 1, 1, 1-trichloro-4-methoxy-3-penten-2-one postulated in the preparation of isoxazole-5-carboxylic acid from trichloroacetyl chloride, ethyl vinyl ether and hydroxylamine is developed in a fully saturated nitrogen atom theerefore there is no possibility of conjugation with 4- substituents.
General Description	Isoxazole-5-carboxylic acid can be obtained via dehydration of 5-trichloromethylisoxazole.

Isoxazole-5-carboxylic acid Preparation Products And Raw materials

Raw materials	Methanol-->Diethyl ether-->Sulfuric acid-->Dichloromethane-->Thionyl chloride-->Hexane-->Lithium Aluminum Hydride-->Pyridine-->Hydroxylamine hydrochloride-->Trifluoroacetic anhydride-->Trichloroacetic acid
Preparation Products	5-Isoxazolecarboxamide,N-methoxy-N-methyl-(9CI)

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