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| | 4-Hydroxypiperidine hydrochloride Basic information |
| Product Name: | 4-Hydroxypiperidine hydrochloride | | Synonyms: | TIMTEC-BB SBB004192;4-HYDROXYPIPERIDINE HYDROCHLORIDE;4-PIPERIDINOL HYDROCHLORIDE;4-PIPIRIDINOL HYDROCHLORIDE;4-Hydroxypiperidine HCl;4-hydroxypiperidinium chloride;4-PiperidinolHCl;2-FLUOROPHENYL HYDRAZINE BASE | | CAS: | 5382-17-2 | | MF: | C5H12ClNO | | MW: | 137.61 | | EINECS: | 226-374-7 | | Product Categories: | Piperidine | | Mol File: | 5382-17-2.mol |  |
| | 4-Hydroxypiperidine hydrochloride Chemical Properties |
| Melting point | 155-157 °C(lit.) | | storage temp. | Inert atmosphere,Room Temperature | | solubility | methanol: soluble25mg/mL, clear, colorless | | form | powder to crystaline | | color | White to Orange to Green | | Water Solubility | very faint turbidity | | BRN | 3908995 | | InChI | 1S/C5H11NO.ClH/c7-5-1-3-6-4-2-5;/h5-7H,1-4H2;1H | | InChIKey | VKCORPXOKYDINR-UHFFFAOYSA-N | | SMILES | Cl[H].OC1CCNCC1 | | CAS DataBase Reference | 5382-17-2(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 3 | | F | 3 | | HS Code | 29333990 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| | 4-Hydroxypiperidine hydrochloride Usage And Synthesis |
| Chemical Properties | White powder | | Uses | 4-Hydroxypiperidine, HCl | | Uses | 4-Hydroxypiperidine hydrochloride is suitable for use in the Ugi-multi component reaction (MCR) to study the use of miniaturised-synthesis and Total Analysis System (mSYNTAS) in solution phase synthesis and on-line analysis of Ugi-MCRs. It may be used in the synthesis of acetic acid-piperidine-4-yl ester. | | General Description | 4-Hydroxypiperidine hydrochloride is a piperidine derivative. The synthesis of 4-hydroxypiperidine has been reported. 4-Hydroxypiperidine participates in the synthesis of 4-(4′-hydroxypiperidino)-4-phenylcyclohexanol and 1-(4-hydroxypiperidino)cyclohexanecarbonitrile. 4-Hydroxypiperidine is the starting material for the synthesis of Sibrafiban and Lamifiban, two non-peptidefibrinogen receptor. | | Synthesis | The general procedure for the synthesis of 4-hydroxypiperidine hydrochloride from N-Boc-4-hydroxypiperidine was as follows: tert-butyl 4-hydroxypiperidine-1-carboxylate (5 g, 24.84 mmol, 1.00 eq.) was mixed with a saturated HCl solution dissolved in 30 mL of 1,4-dioxane, and the reaction was stirred for 2 h at room temperature. Upon completion of the reaction, the mixture was concentrated in vacuum to afford 4-hydroxypiperidine hydrochloride (3.4 g, 99% yield) as an off-white solid. | | References | [1] Patent: WO2015/52264, 2015, A1. Location in patent: Paragraph 0918; 0919
[2] Patent: WO2017/153520, 2017, A1. Location in patent: Page/Page column 50
[3] Patent: WO2016/34673, 2016, A1. Location in patent: Page/Page column 120 |
| | 4-Hydroxypiperidine hydrochloride Preparation Products And Raw materials |
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