| Company Name: |
Hangzhou Milestone Pharmtech Co., Ltd.
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| Tel: |
0571-82896630 18969958410 |
| Email: |
sales_hz@milestonepharmtech.com |
| Products Intro: |
Product Name:CYP11B2-IN-1
CAS:1356479-78-1
Purity:95% Package:50；100；250；1000G
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| Company Name: |
Shanghai Yifei Biotechnology Co. , Ltd.
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| Tel: |
021-65675885 18964387627 |
| Email: |
customer_service@efebio.com |
| Products Intro: |
Product Name:CYP11B2-IN-1
CAS:1356479-78-1
Purity:98.00% Package:1mg;2mg;5mg
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| | CYP11B2-IN-1 Basic information |
| Product Name: | CYP11B2-IN-1 | | Synonyms: | CYP11B2-IN-1;CYP11B2 IN 1,CYP-11B2-IN-1,CYP11B2IN1;3-Pyridinemethanol, 5-(1-cyclopropyl-6-fluoro-1H-benzimidazol-2-yl)-α,α-dimethyl-;2-[5-(1-cyclopropyl-6-fluoro-1h-benzimidazol-2-yl)pyridin-3-yl]propan-2-ol;CYP11B2-IN-1, 10 mM in DMSO | | CAS: | 1356479-78-1 | | MF: | C18H18FN3O | | MW: | 311.35 | | EINECS: | | | Product Categories: | | | Mol File: | 1356479-78-1.mol |  |
| | CYP11B2-IN-1 Chemical Properties |
| Boiling point | 528.5±60.0 °C(Predicted) | | density | 1.34±0.1 g/cm3(Predicted) | | pka | 13.62±0.29(Predicted) | | form | Solid | | color | Off-white to light yellow |
| | CYP11B2-IN-1 Usage And Synthesis |
| Uses | CYP11B2-IN-1 is a CYP11B2 inhibitor with an IC50 of 2.3 nM. CYP11B2-IN-1 inhibits CYP11B1 with an IC50 of 142 nM[1]. | | in vivo | In a rhesus pharmacodynamic model, CYP11B2-IN-1 (Compound 32) produces dose-dependent aldosterone lowering efficacy, with no apparent effect on cortisol levels[1].
CYP11B2-IN-1also displays a good rhesus pharmacokinetics profile, with low plasma clearance and acceptable oral exposure.When dosed i.v. at 0.01 and 0.3 mg/kg, CYP11B2-IN-1 produces reductions in aldosterone AUC of 62% and 95%, respectively, compared to baseline[1]. | | IC 50 | CYP11B2: 2.3 nM (IC50); CYP11B1: 142 nM (IC50) | | References | [1] Hoyt SB, et al. Discovery of Benzimidazole CYP11B2 Inhibitors with in Vivo Activity in Rhesus Monkeys.ACS Med Chem Lett. 2015 Apr 7;6(5):573-8. DOI:10.1021/acsmedchemlett.5b00054 |
| | CYP11B2-IN-1 Preparation Products And Raw materials |
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