| Company Name: |
InvivoChem |
| Tel: |
+1-708-310-1919 +1-13798911105 |
| Email: |
sales@invivochem.cn |
| Company Name: |
InvivoChem |
| Tel: |
13549236410 |
| Email: |
sales@invivochem.cn |
|
| | SMS2-IN-1 Basic information |
| Product Name: | SMS2-IN-1 | | Synonyms: | SMS2-IN-1;1-methylcyclopropyl 4-(3-((3-((3,5-bis(trifluoromethyl)benzyl)(methyl)carbamoyl)-1-methyl-2-oxo-1,2-dihydroquinolin-4-yl)oxy)propyl)piperidine-1-carboxylate;JUN90152;SMS2 IN 1,SMS2IN1,SMS-2-IN-1;1-Piperidinecarboxylic acid, 4-[3-[[3-[[[[3,5-bis(trifluoromethyl)phenyl]methyl]methylamino]carbonyl]-1,2-dihydro-1-methyl-2-oxo-4-quinolinyl]oxy]propyl]-, 1-methylcyclopropyl ester | | CAS: | 2098890-15-2 | | MF: | C34H37F6N3O5 | | MW: | 681.67 | | EINECS: | | | Product Categories: | | | Mol File: | 2098890-15-2.mol |  |
| | SMS2-IN-1 Chemical Properties |
| Boiling point | 685.7±55.0 °C(Predicted) | | density | 1.37±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO : 27.78 mg/mL (40.75 mM; Need ultrasonic) | | pka | -1.20±0.20(Predicted) | | form | Solid | | color | White to off-white |
| | SMS2-IN-1 Usage And Synthesis |
| Uses | SMS2-IN-1 is a potent and highly selective sphingomyelin synthase 2 (SMS2) inhibitor with an IC50 of 6.5 nM and a Kd of 37 nM. SMS2-IN-1 shows 150-fold selectivity for SMS2 over SMS1 (IC50 of 1000 nM)[1]. | | References | [1] Adachi R, et al. Discovery and characterization of selective human sphingomyelin synthase 2 inhibitors. Eur J Med Chem. 2017 Aug 18;136:283-293. DOI:10.1016/j.ejmech.2017.04.067 |
| | SMS2-IN-1 Preparation Products And Raw materials |
|