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| | Mal-PEG2-oxyamine Basic information |
| Product Name: | Mal-PEG2-oxyamine | | Synonyms: | Mal-PEG2-oxyamine;1H-Pyrrole-2,5-dione, 1-[2-[2-[2-(aminooxy)ethoxy]ethoxy]ethyl]-;1-(2-{2-[2-(aminooxy)ethoxy]ethoxy}ethyl)-2,5-dihydro-1H-pyrrole-2,5-dione | | CAS: | 1146245-73-9 | | MF: | C10H16N2O5 | | MW: | 244.24 | | EINECS: | | | Product Categories: | | | Mol File: | 1146245-73-9.mol |  |
| | Mal-PEG2-oxyamine Chemical Properties |
| Boiling point | 424.3±35.0 °C(Predicted) | | density | 1.269±0.06 g/cm3(Predicted) | | pka | 4.21±0.70(Predicted) | | form | Oil | | color | Colorless to light yellow |
| | Mal-PEG2-oxyamine Usage And Synthesis |
| Uses | Mal-PEG2-oxyamine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | | Biological Activity | Mal-PEG2-oxyamine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. | | IC 50 | PEGs | | References | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. |
| | Mal-PEG2-oxyamine Preparation Products And Raw materials |
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