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BOC Sciences |
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1-631-485-4226; 16314854226 |
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info@bocsci.com |
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| | Nesvacumab Basic information |
| Product Name: | Nesvacumab | | Synonyms: | Nesvacumab;Research Grade Nesvacumab(DHA42303);Research Grade Nesvacumab;Nesvacumab (anti-ANGPT2) | | CAS: | 1296818-77-3 | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![Nesvacumab Structure]() |
| | Nesvacumab Chemical Properties |
| form | Liquid | | color | Colorless to light yellow |
| | Nesvacumab Usage And Synthesis |
| Uses | Nesvacumab is a fully human immunoglobulin G1 (IgG1) monoclonal antibody that specifically binds and inactivates the Tie2 receptor ligand Angiopoietin-2 (Ang2) with high affinity, but shows no binding to Ang1[1]. | | Biological Activity | Nesvacumab is an experimental monoclonal antibody originally designed for the treatment of cancer. It targets the protein angiopoietin 2. As of May 2017, it is in Phase II clinical trials for the treatment of diabetic macular edema. | | References | [1] Kyriakos P Papadopoulos, et al. A Phase I First-in-Human Study of Nesvacumab (REGN910), a Fully Human Anti-Angiopoietin-2 (Ang2) Monoclonal Antibody, in Patients with Advanced Solid Tumors. Clin Cancer Res. 2016 Mar 15;22(6):1348-55. DOI:10.1158/1078-0432.CCR-15-1221 |
| | Nesvacumab Preparation Products And Raw materials |
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