2,4-Pyrimidinediamine, N2-(3,5-di-4-morpholinylphenyl)-N4-1H-indazol-4-yl-N4-methyl-

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2,4-Pyrimidinediamine, N2-(3,5-di-4-morpholinylphenyl)-N4-1H-indazol-4-yl-N4-methyl- manufacturers

  • AZ12672857
  • AZ12672857 pictures
  • $64.00
  • 2026-09-10
  • CAS:945396-55-4
  • Purity: 98.99%
  • Supply Ability: 10g
2,4-Pyrimidinediamine, N2-(3,5-di-4-morpholinylphenyl)-N4-1H-indazol-4-yl-N4-methyl- Basic information
Product Name:2,4-Pyrimidinediamine, N2-(3,5-di-4-morpholinylphenyl)-N4-1H-indazol-4-yl-N4-methyl-
Synonyms:2,4-Pyrimidinediamine, N2-(3,5-di-4-morpholinylphenyl)-N4-1H-indazol-4-yl-N4-methyl-;AZ12672857;AZ12672857, 10 mM in DMSO
CAS:945396-55-4
MF:C26H30N8O2
MW:486.57
EINECS:
Product Categories:
Mol File:945396-55-4.mol
2,4-Pyrimidinediamine, N2-(3,5-di-4-morpholinylphenyl)-N4-1H-indazol-4-yl-N4-methyl- Structure
2,4-Pyrimidinediamine, N2-(3,5-di-4-morpholinylphenyl)-N4-1H-indazol-4-yl-N4-methyl- Chemical Properties
storage temp. Store at -20°C
solubility DMSO: 25 mg/mL (51.38 mM)
form Solid
color Light brown to brown
Safety Information
MSDS Information
2,4-Pyrimidinediamine, N2-(3,5-di-4-morpholinylphenyl)-N4-1H-indazol-4-yl-N4-methyl- Usage And Synthesis
UsesAZ12672857 is an orally active inhibitor of EphB4 (IC50=1.3 nM) and Src kinases. AZ12672857 shows good inhibition of proliferation of c-Src transfected 3T3 cells (IC50=2 nM) as well as autophosphorylation of EphB4 in transfected CHO-K1 cells (IC50=9 nM)[1].
IC 50Src
References[1] Bardelle C, et al. Inhibitors of the tyrosine kinase EphB4. Part 3: identification of non-benzodioxole-based kinase inhibitors. Bioorg Med Chem Lett. 2010;20(21):6242-6245. DOI:10.1016/j.bmcl.2010.08.100
2,4-Pyrimidinediamine, N2-(3,5-di-4-morpholinylphenyl)-N4-1H-indazol-4-yl-N4-methyl- Preparation Products And Raw materials
Tag:2,4-Pyrimidinediamine, N2-(3,5-di-4-morpholinylphenyl)-N4-1H-indazol-4-yl-N4-methyl-(945396-55-4) Related Product Information
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