L-Glutamic acid, N-[4-[4-(2-amino-3,4-dihydro-4-oxo-5H-pyrrolo[3,2-d]pyrimidin-5-yl)butyl]-2-fluorobenzoyl]-

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L-Glutamic acid, N-[4-[4-(2-amino-3,4-dihydro-4-oxo-5H-pyrrolo[3,2-d]pyrimidin-5-yl)butyl]-2-fluorobenzoyl]- Basic information
Product Name:L-Glutamic acid, N-[4-[4-(2-amino-3,4-dihydro-4-oxo-5H-pyrrolo[3,2-d]pyrimidin-5-yl)butyl]-2-fluorobenzoyl]-
Synonyms:L-Glutamic acid, N-[4-[4-(2-amino-3,4-dihydro-4-oxo-5H-pyrrolo[3,2-d]pyrimidin-5-yl)butyl]-2-fluorobenzoyl]-;AGF347
CAS:2294820-23-6
MF:C22H24FN5O6
MW:473.45
EINECS:
Product Categories:
Mol File:2294820-23-6.mol
L-Glutamic acid, N-[4-[4-(2-amino-3,4-dihydro-4-oxo-5H-pyrrolo[3,2-d]pyrimidin-5-yl)butyl]-2-fluorobenzoyl]- Structure
L-Glutamic acid, N-[4-[4-(2-amino-3,4-dihydro-4-oxo-5H-pyrrolo[3,2-d]pyrimidin-5-yl)butyl]-2-fluorobenzoyl]- Chemical Properties
density 1.53±0.1 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO: 2mg/L, clear
pka3.53±0.10(Predicted)
form powder
color white to beige
SMILESO=C(CC[C@H](NC(C1=CC=C(C=C1F)CCCCN2C=CC(N=C(N3)N)=C2C3=O)=O)C(O)=O)O
Safety Information
WGK Germany WGK 3
Storage Class11 - Combustible Solids
MSDS Information
L-Glutamic acid, N-[4-[4-(2-amino-3,4-dihydro-4-oxo-5H-pyrrolo[3,2-d]pyrimidin-5-yl)butyl]-2-fluorobenzoyl]- Usage And Synthesis
Biological ActivityAGF347 is a potent inhibitor of serine hydroxymethyltransferase 2 (SHMT2) th at inhibits mitochondrial C1 metabolism. It also inhibits cytosolic C1 targets such as SHMT1, GARFTase, and AICARFTase. AGF347 inhibits de novo purine biosynthesis. AGF347 exhibits potent broad spectrum in vitro and in vivo antitumor efficacy.
L-Glutamic acid, N-[4-[4-(2-amino-3,4-dihydro-4-oxo-5H-pyrrolo[3,2-d]pyrimidin-5-yl)butyl]-2-fluorobenzoyl]- Preparation Products And Raw materials
Tag:L-Glutamic acid, N-[4-[4-(2-amino-3,4-dihydro-4-oxo-5H-pyrrolo[3,2-d]pyrimidin-5-yl)butyl]-2-fluorobenzoyl]-(2294820-23-6) Related Product Information