Thalidomide-NH-CH2-COOH manufacturers
- Thalidomide-NH-CH2-COOH
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- $0.00 / 25kg
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2025-12-01
- CAS:927670-97-1
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 10000KGS
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| | Thalidomide-NH-CH2-COOH Basic information |
| Product Name: | Thalidomide-NH-CH2-COOH | | Synonyms: | [(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl)amino]acetic acid;Glycine, N-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]-;Thalidomide-NH-CH2-COOH;3-dioxoisoindol-4-yl]amino]acetic acid;3-dioxoisoindolin-4-yl)glycine;6-dioxopiperidin-3-yl)-1;(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)glycine;inhibit,Ligands for E3 Ligase,E3 ligase-recruiting Moiety,Inhibitor,Thalidomide NH CH2 COOH,ThalidomideNHCH2COOH,cereblon,Thalidomide-NH-CH-2-COOH,CRBN,Thalidomide | | CAS: | 927670-97-1 | | MF: | C15H13N3O6 | | MW: | 331.28 | | EINECS: | | | Product Categories: | | | Mol File: | 927670-97-1.mol |  |
| | Thalidomide-NH-CH2-COOH Chemical Properties |
| Boiling point | 713.9±60.0 °C(Predicted) | | density | 1.637±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | DMSO : 50 mg/mL (150.93 mM; Need ultrasonic) | | form | Solid | | pka | 3.92±0.10(Predicted) | | color | Light yellow to green yellow | | InChI | InChI=1S/C15H13N3O6/c19-10-5-4-9(13(22)17-10)18-14(23)7-2-1-3-8(12(7)15(18)24)16-6-11(20)21/h1-3,9,16H,4-6H2,(H,20,21)(H,17,19,22) | | InChIKey | LRGLFYOYKPSPJQ-UHFFFAOYSA-N | | SMILES | C(O)(=O)CNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Repr. 2
STOT RE 2 |
| | Thalidomide-NH-CH2-COOH Usage And Synthesis |
| Uses | Thalidomide-NH-CH2-COOH is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-NH-CH2-COOH can be connected to the ligand for protein by a linker to form PROTACs, such as THAL-SNS-032 (HY-123937)[1]. | | Definition |
Thalidomide-NH-CH2-COOH contains a thalidomide group, an amide, an alkylC2 chain, and a terminal carboxylic acid. This product is ready for conjugation to target proteins for PROTAC R&D. It is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. This compound also can be connected to the ligand for protein by a linker to form PROTACs, such as THAL-SNS-032 (HY-123937).
| | IC 50 | Cereblon | | References | [1] Calla M Olson, et al. Pharmacological perturbation of CDK9 using selective CDK9 inhibition or degradation. Nat Chem Biol. 2018 Feb;14(2):163-170. DOI:10.1038/nchembio.2538 |
| | Thalidomide-NH-CH2-COOH Preparation Products And Raw materials |
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