Benzonitrile, 4-[[5-[4-fluoro-1-(1H-indazol-6-yl)-1H-benzotriazol-6-yl]-1H-pyrazol-1-yl]methyl]-

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Benzonitrile, 4-[[5-[4-fluoro-1-(1H-indazol-6-yl)-1H-benzotriazol-6-yl]-1H-pyrazol-1-yl]methyl]- Basic information
Product Name:Benzonitrile, 4-[[5-[4-fluoro-1-(1H-indazol-6-yl)-1H-benzotriazol-6-yl]-1H-pyrazol-1-yl]methyl]-
Synonyms:Benzonitrile, 4-[[5-[4-fluoro-1-(1H-indazol-6-yl)-1H-benzotriazol-6-yl]-1H-pyrazol-1-yl]methyl]-;CD73-IN-5
CAS:2412019-99-7
MF:C24H15FN8
MW:434.43
EINECS:
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Mol File:2412019-99-7.mol
Benzonitrile, 4-[[5-[4-fluoro-1-(1H-indazol-6-yl)-1H-benzotriazol-6-yl]-1H-pyrazol-1-yl]methyl]- Structure
Benzonitrile, 4-[[5-[4-fluoro-1-(1H-indazol-6-yl)-1H-benzotriazol-6-yl]-1H-pyrazol-1-yl]methyl]- Chemical Properties
Boiling point 765.9±70.0 °C(Predicted)
density 1.48±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO : ≥ 50 mg/mL (115.09 mM)
pka11.74±0.40(Predicted)
form Solid
color Off-white to light yellow
Safety Information
MSDS Information
Benzonitrile, 4-[[5-[4-fluoro-1-(1H-indazol-6-yl)-1H-benzotriazol-6-yl]-1H-pyrazol-1-yl]methyl]- Usage And Synthesis
UsesCD73-IN-5 is a potent and selective non-nucleotide small molecule inhibitor of CD73 (IC50 = 19 nM).
References[1] Beatty JW, et al. Discovery of Potent and Selective Non-Nucleotide Small Molecule Inhibitors of CD73. J Med Chem. 2020 Apr 23;63(8):3935-3955. DOI:10.1021/acs.jmedchem.9b01713
Benzonitrile, 4-[[5-[4-fluoro-1-(1H-indazol-6-yl)-1H-benzotriazol-6-yl]-1H-pyrazol-1-yl]methyl]- Preparation Products And Raw materials
Tag:Benzonitrile, 4-[[5-[4-fluoro-1-(1H-indazol-6-yl)-1H-benzotriazol-6-yl]-1H-pyrazol-1-yl]methyl]-(2412019-99-7) Related Product Information
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