1H-Benzimidazole-2-methanol, 6-[5-chloro-2-[[(3R,4R)-3-hydroxy-1-(methylsulfonyl)-4-piperidinyl]amino]-4-pyrimidinyl]-4-fluoro-α-methyl-1-(1-methylethyl)-, (αR)-

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1H-Benzimidazole-2-methanol, 6-[5-chloro-2-[[(3R,4R)-3-hydroxy-1-(methylsulfonyl)-4-piperidinyl]amino]-4-pyrimidinyl]-4-fluoro-α-methyl-1-(1-methylethyl)-, (αR)- Suppliers list
Company Name: BOC Sciences
Tel: 16314854226; +8616314854226
Email: inquiry@bocsci.com
Products Intro: Product Name:CDK4/6-IN-5
CAS:2380321-50-4
Purity:96% Remarks:Please reach out to us for more information about custom solutions.
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.cn
Products Intro: Product Name:CDK4/6-IN-5
CAS:2380321-50-4
Package:1removed
1H-Benzimidazole-2-methanol, 6-[5-chloro-2-[[(3R,4R)-3-hydroxy-1-(methylsulfonyl)-4-piperidinyl]amino]-4-pyrimidinyl]-4-fluoro-α-methyl-1-(1-methylethyl)-, (αR)- Basic information
Product Name:1H-Benzimidazole-2-methanol, 6-[5-chloro-2-[[(3R,4R)-3-hydroxy-1-(methylsulfonyl)-4-piperidinyl]amino]-4-pyrimidinyl]-4-fluoro-α-methyl-1-(1-methylethyl)-, (αR)-
Synonyms:1H-Benzimidazole-2-methanol, 6-[5-chloro-2-[[(3R,4R)-3-hydroxy-1-(methylsulfonyl)-4-piperidinyl]amino]-4-pyrimidinyl]-4-fluoro-α-methyl-1-(1-methylethyl)-, (αR)-;(3R,4R)-4-[(5-chloro-4-{4-fluoro-2-[(1 R)-1 -hydroxyethyl]-1 -(propan-2-yl)-1 H-benzimidazol-6-yl}pyrimidin-2-yl)amino]-1-(methylsulfonyl)piperidin-3-ol 1 -[(1S,2R,3R,4R,5S)-4-(acetylamino)-2,3-bis(acetyloxy)-6,8-dioxabicyclo[3.2.1 ]oct-1 -yl]-18,18-bis(17-;CDK4/6-IN-5
CAS:2380321-50-4
MF:C22H28ClFN6O4S
MW:527.01
EINECS:
Product Categories:
Mol File:2380321-50-4.mol
1H-Benzimidazole-2-methanol, 6-[5-chloro-2-[[(3R,4R)-3-hydroxy-1-(methylsulfonyl)-4-piperidinyl]amino]-4-pyrimidinyl]-4-fluoro-α-methyl-1-(1-methylethyl)-, (αR)- Structure
1H-Benzimidazole-2-methanol, 6-[5-chloro-2-[[(3R,4R)-3-hydroxy-1-(methylsulfonyl)-4-piperidinyl]amino]-4-pyrimidinyl]-4-fluoro-α-methyl-1-(1-methylethyl)-, (αR)- Chemical Properties
Boiling point 752.7±70.0 °C(Predicted)
density 1.56±0.1 g/cm3(Predicted)
pka13.36±0.20(Predicted)
Safety Information
MSDS Information
1H-Benzimidazole-2-methanol, 6-[5-chloro-2-[[(3R,4R)-3-hydroxy-1-(methylsulfonyl)-4-piperidinyl]amino]-4-pyrimidinyl]-4-fluoro-α-methyl-1-(1-methylethyl)-, (αR)- Usage And Synthesis
UsesCDK4/6-IN-5 is a potent CDK4 and CDK6 inhibitor with Kis of 0.2 and 4.4 nM for CDK4/Cyclin D1 and CDK6/Cyclin D3, respectively[1]. (from patent WO2019207463A1 example A93).
References[1] Ping Chen, et al. 2-amino-pyridine or 2-amino-pyrimidine derivatives as cyclin dependent kinase inhibitors. WO2019207463A1.
1H-Benzimidazole-2-methanol, 6-[5-chloro-2-[[(3R,4R)-3-hydroxy-1-(methylsulfonyl)-4-piperidinyl]amino]-4-pyrimidinyl]-4-fluoro-α-methyl-1-(1-methylethyl)-, (αR)- Preparation Products And Raw materials
Tag:1H-Benzimidazole-2-methanol, 6-[5-chloro-2-[[(3R,4R)-3-hydroxy-1-(methylsulfonyl)-4-piperidinyl]amino]-4-pyrimidinyl]-4-fluoro-α-methyl-1-(1-methylethyl)-, (αR)-(2380321-50-4) Related Product Information