Acetamide, 2-[[5-[(2-methylphenoxy)methyl]-4-phenyl-4H-1,2,4-triazol-3-yl]thio]-

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Acetamide, 2-[[5-[(2-methylphenoxy)methyl]-4-phenyl-4H-1,2,4-triazol-3-yl]thio]- Basic information
Product Name:Acetamide, 2-[[5-[(2-methylphenoxy)methyl]-4-phenyl-4H-1,2,4-triazol-3-yl]thio]-
Synonyms:Acetamide, 2-[[5-[(2-methylphenoxy)methyl]-4-phenyl-4H-1,2,4-triazol-3-yl]thio]-;A2ti-2;A2ti2,A-2ti-2,A2ti 2;2-((4-Phenyl-5-((o-tolyloxy)methyl)-4H-1,2,4-triazol-3-yl)thio)acetamide
CAS:482646-13-9
MF:C18H18N4O2S
MW:354.43
EINECS:
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Mol File:482646-13-9.mol
Acetamide, 2-[[5-[(2-methylphenoxy)methyl]-4-phenyl-4H-1,2,4-triazol-3-yl]thio]- Structure
Acetamide, 2-[[5-[(2-methylphenoxy)methyl]-4-phenyl-4H-1,2,4-triazol-3-yl]thio]- Chemical Properties
Boiling point 626.5±65.0 °C(Predicted)
density 1.30±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO : 250 mg/mL (705.36 mM)
pka15.07±0.40(Predicted)
form Solid
color White to off-white
Safety Information
MSDS Information
Acetamide, 2-[[5-[(2-methylphenoxy)methyl]-4-phenyl-4H-1,2,4-triazol-3-yl]thio]- Usage And Synthesis
UsesA2ti-2 is a selective and low-affinity annexin A2/S100A10 heterotetramer (A2t) inhibitor with an IC50 of 230 μM[1]. A2ti-2 specifically disrupts the protein-protein interaction (PPI) between A2 and S100A10. A2ti-2 prevents human papillomavirus type 16 (HPV16) infection[2].
References[1] Tummala R K Reddy, et al.Three-dimensional Pharmacophore Design and Biochemical Screening Identifies Substituted 1,2,4-triazoles as Inhibitors of the Annexin A2-S100A10 Protein Interaction. ChemMedChem. 2012 Aug;7(8):1435-46. DOI:10.1002/cmdc.201200107
[2] Andrew W Woodham, et al. Small Molecule Inhibitors of the Annexin A2 Heterotetramer Prevent Human Papillomavirus Type 16 Infection. J Antimicrob Chemother. 2015;70(6):1686-90. DOI:10.1093/jac/dkv045
Acetamide, 2-[[5-[(2-methylphenoxy)methyl]-4-phenyl-4H-1,2,4-triazol-3-yl]thio]- Preparation Products And Raw materials
Tag:Acetamide, 2-[[5-[(2-methylphenoxy)methyl]-4-phenyl-4H-1,2,4-triazol-3-yl]thio]-(482646-13-9) Related Product Information
N-(4-ethoxyphenyl)-2-[(4-methyl-5-{[5-methyl-2-(propan-2-yl)phenoxy]methyl}-4H-1,2,4-triazol-3-yl)sulfanyl]acetamide 2-[(4,5-diphenyl-1,2,4-triazol-3-yl)sulfanyl]-N-[(E)-(2-methoxyphenyl)methylideneamino]acetamide Acetic acid, 2-[[5-(4-methoxyphenyl)-4-phenyl-4H-1,2,4-triazol-3-yl]thio]-, hydrazide 5-[(2,6-Dimethylphenoxy)methyl]-4-phenyl-4H-1,2,4-triazole-3-thiol N-(4-ethoxyphenyl)-2-[[5-(3-methoxyphenyl)-4-(4-methoxyphenyl)-1,2,4-triazol-3-yl]sulfanyl]acetamide (5-[(3,4-Dichlorobenzyl)sulfanyl]-4-phenyl-4H-1,2,4-triazol-3-yl)methyl 1-naphthyl ether