N-[2-[P-溴苯丙烯盐基氨基]乙基]-5-异喹啉磺酰胺
| 中文名称 | N-[2-[P-溴苯丙烯盐基氨基]乙基]-5-异喹啉磺酰胺 |
|---|---|
| 中文同义词 | N-[2-[[3-(4-溴苯基)-2-丙烯-1-基]氨基]乙基]-5-异喹啉磺酰胺;N-[2-[P-溴苯丙烯盐基氨基]乙基]-5-异喹啉磺酰胺;H-89二盐酸盐, 一种高效的选择性PKA抑制剂;N-[2-[P-溴苯丙烯盐基氨基]乙基]-5-异喹啉磺酰胺二盐酸盐(H-89二盐酸盐);N - [2 - (P溴肉桂氨基酸乙基] -5 - 异喹啉磺胺类药物;(BASE),H-89 & H-89 2HCL游离,盐酸盐;化合物 H-89;化合物:H 89 CAS:127243-85-0 |
| 英文名称 | N-(2-[P-BROMOCINNAMYLAMINO]ETHYL)-5-ISOQUINOLINESULFONAMIDE HYDROCHLORIDE |
| 英文同义词 | H-89;H-89 DIHYDROCHLORIDE;H-89 HYDROCHLORIDE;N-[2-(P-BROMOCINNAMYLAMINO)ETHYL]-5-ISOQUINOLINE SULFONAMIDE;N-[2-(P-BROMOCINNAMYLAMINO)ETHYL]-5-ISOQUINOLINESULFONAMIDE 2HCL;N-[2-(P-BROMOCINNAMYLAMINO)ETHYL]-5-ISOQUINOLINE SULFONAMIDE, DIHYDROCHLORIDE;N-(2-[P-BROMOCINNAMYLAMINO]ETHYL)-5-ISOQUINOLINESULFONAMIDE HYDROCHLORIDE;N-[2-[P-BROMOCINNAMYLAMINO]-ETHYL]-5-ISOQUINOLINESULFONMIDE |
| CAS号 | 127243-85-0 |
| 分子式 | C20H20BrN3O2S |
| 分子量 | 446.36 |
| EINECS号 | |
| 相关类别 | 定制化学品;医药中间体;Inhibitor;Protein Kinase Inhibitors and Activators |
| Mol文件 | 127243-85-0.mol |
| 结构式 | ![N-[2-[P-溴苯丙烯盐基氨基]乙基]-5-异喹啉磺酰胺 结构式](CAS/GIF/127243-85-0.gif) |
N-[2-[P-溴苯丙烯盐基氨基]乙基]-5-异喹啉磺酰胺 性质
| 熔点 | 195-200°C |
|---|---|
| 沸点 | 639.7±65.0 °C(Predicted) |
| 密度 | 1.436 |
| 储存条件 | 2-8°C |
| 溶解度 | H2O: ≥10 mg/mL |
| 酸度系数(pKa) | 10.43±0.50(Predicted) |
| 形态 | 粉末 |
| 颜色 | 米白色 |
| 稳定性 | 自购买之日起，稳定期为 1 年。 其DMSO 或蒸馏水中的溶液可在 -20°C 下保存长达 3 个月。 |
| 化妆品成分功效 | SKIN CONDITIONING - MISCELLANEOUS BLEACHING |
| InChI | 1S/C20H20BrN3O2S/c21-18-8-6-16(7-9-18)3-2-11-22-13-14-24-27(25,26)20-5-1-4-17-15-23-12-10-19(17)20/h1-10,12,15,22,24H,11,13-14H2/b3-2+ |
| InChIKey | ZKZXNDJNWUTGDK-NSCUHMNNSA-N |
| SMILES | [S](=O)(=O)(NCCNC\C=C\c3ccc(cc3)Br)c1c2c(cncc2)ccc1 |
| CAS 数据库 | 127243-85-0(CAS DataBase Reference) |
IC50: 48 nM (protein kinase A)
H-89 inhibits protein kinase A, in competitive fashion against ATP. H-89 causes a dose-dependent inhibition of the forskolin-induced protein phosphorylation, with no decrease in intracellular cyclic AMP levels in PC12D cells. H-89 significantly inhibits the forskolin-induced neurite outgrowth from PC12D cells. H-89 (30 μM) inhibits significantly cAMP-dependent histone IIb phosphorylation activity in PC12D cell lysates. H-89 (1-2 μM) significantly slows the repriming rate in rat skinned fibres, most likely due to it deleteriously affecting the T-system potential. H-89 (10-100 μM) inhibits net Ca 2+ uptake by the SR and affectes the Ca 32 -sensitivity of the contractile apparatus in rat skinned fibres.
H-89 (0.2 mg/100g, i.p.) significantly increases seizure latency and threshold in PTZ-treated animals. H-89 (0.05, 0.2 mg/100 g, i.p.) prevents the epileptogenic activity of bucladesine (300 nM) with significant increase of seizure latency and seizure threshold.
安全信息
| 安全说明 | 22-24/25 |
|---|---|
| WGK Germany | 3 |
| 海关编码 | 29350090 |
| 存储类别 | 11 - 可燃固体 |
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2025/12/22 | HY-15979A | N-[2-[P-溴苯丙烯盐基氨基]乙基]-5-异喹啉磺酰胺 H-89 dihydrochloride | 127243-85-0 | 5 mg | 385元 |
| 2025/12/22 | HY-15979A | N-[2-[P-溴苯丙烯盐基氨基]乙基]-5-异喹啉磺酰胺 H-89 dihydrochloride | 127243-85-0 | 10mg | 606元 |