Val-Lys(Boc)-PAB

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Company Name: Shanghai YuanYe Biotechnology Co., Ltd.  
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Company Name: InvivoChem  
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Val-Lys(Boc)-PAB Basic information
Product Name:Val-Lys(Boc)-PAB
Synonyms:Val-Lys(Boc)-PAB;tert-Butyl ((S)-5-((S)-2-amino-3-methylbutana mido)-6-((4-(hydroxymethyl)phenyl)amino)-6-.;tert-Butyl ((S)-5-((S)-2-amino-3-methylbutanamido)-6-((4-(hydroxymethyl)phenyl)amino)-6-oxohexyl)carbamate;L-Lysinamide, L-valyl-N6-[(1,1-dimethylethoxy)carbonyl]-N-[4-(hydroxymethyl)phenyl]-
CAS:1432969-86-2
MF:C23H38N4O5
MW:450.57
EINECS:
Product Categories:
Mol File:1432969-86-2.mol
Val-Lys(Boc)-PAB Structure
Val-Lys(Boc)-PAB Chemical Properties
Boiling point 722.6±60.0 °C(Predicted)
density 1.153±0.06 g/cm3(Predicted)
storage temp. Storage temp. 2-8°C
solubility DMSO : 125 mg/mL (277.43 mM; Need ultrasonic)
form Solid
pka12.87±0.46(Predicted)
color White to off-white
Safety Information
MSDS Information
Val-Lys(Boc)-PAB Usage And Synthesis
UsesPAB-Val-Lys-Boc is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) for stimulating an immune response[1].
Biological ActivityPAB-Val-Lys-Boc is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) for stimulating an immune response[1].
IC 50Protease Cleavable Linker; Cleavable Linker
References[1]. Geoffrey Alan Pietersz. Immunomodulatory conjugates. WO2013067597A1 (compound PEG-A)
Val-Lys(Boc)-PAB Preparation Products And Raw materials
Tag:Val-Lys(Boc)-PAB(1432969-86-2) Related Product Information
1-Pyrrolidinecarboxylic acid, 2-[[(2,3-dimethylphenyl)amino]carbonyl]-, phenylmethyl ester, (2S)- L-Lysinamide, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-valyl-N6-[(1,1-dimethylethoxy)carbonyl]-N-[4-(hydroxymethyl)phenyl]- Carbamic acid, (2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-3-yl)-, phenylmethyl ester (9CI) Carbamic acid, N-[(1S)-1-(cyclohexylmethyl)-2-[[(1S)-1-formyl-2-[(3S)-2-oxo-3-pyrrolidinyl]ethyl]amino]-2-oxoethyl]-, phenylmethyl ester 2-Pyrazinecarboxamide, N-[3-[(4R,5R,6R)-2-amino-5-fluoro-5,6-dihydro-4,6-dimethyl-4H-1,3-thiazin-4-yl]-4-fluorophenyl]-5-(fluoromethoxy)- L-Ornithinamide, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(10,10-dimethyl-3,8-dioxo-2,9-dioxa-4,7-diazaundec-1-yl)phenyl]-