adenosine 5'-monophosphate, monoanhydride with (phosphonomethyl)phosphonic acid
| 中文名称 | adenosine 5'-monophosphate, monoanhydride with (phosphonomethyl)phosphonic acid |
|---|---|
| 中文同义词 | 化合物 T13547;化合物 AMP-PCP;β,γ-亚甲基腺苷三磷酸 |
| 英文名称 | adenosine 5'-monophosphate, monoanhydride with (phosphonomethyl)phosphonic acid |
| 英文同义词 | adenosine 5'-monophosphate, monoanhydride with (phosphonomethyl)phosphonic acid;5'-adenylyl (beta,gamma-methylene)diphosphonate;5'-Adenylic acid (phosphonomethyl)phosphonyl ester;Adenylyl methylenediphosphonate;AMP-P(CH2)P;β,γ-Methylene ATP;β,γ-MethyleneATP;5'-Adenylic acid, monohydride with methylenebis(phosphonic acid) |
| CAS号 | 3469-78-1 |
| 分子式 | C11H18N5O12P3 |
| 分子量 | 505.21 |
| EINECS号 | 222-435-7 |
| 相关类别 | |
| Mol文件 | 3469-78-1.mol |
| 结构式 |  |
adenosine 5'-monophosphate, monoanhydride with (phosphonomethyl)phosphonic acid 性质
| 沸点 | 968.2±75.0 °C(Predicted) |
|---|---|
| 密度 | 2.50±0.1 g/cm3(Predicted) |
| 酸度系数(pKa) | 0.68±0.10(Predicted) |
AMP-PCP 是一种 ATP 类似物，可以以 Kd 值 为 3.8 μM 来结合到 Hsp90 的 N 末端结构域。AMP-PCP 结合有利于 Hsp90 活性同型二聚体的形成。
|
HSP90 3.8 μM (Kd) |
AMP-PCP binding favors the formation of the active homodimer of Hsp90 by enhancing the slow-motion featured conformational exchanges of those residues (A117-A141) within the lid segment (A111-G135) and around region. In total, 170 non-proline residues are identified for the triple-labeled Hsp90 bound with AMP-PCP.