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Product Name:9(E),11(E),13(E)-Octadecatrienoic acid
CAS:544-73-0
Purity:98%+ Package:1g;10g;100g;1KG;5KG
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| | (9E,11E,13E)-9,11,13-octadecatrienoic acid Basic information |
| Product Name: | (9E,11E,13E)-9,11,13-octadecatrienoic acid | | Synonyms: | (9E,11E,13E)-9,11,13-octadecatrienoic acid;(9E,11E,13E)-9,11,13-Octadecatriensure;Fettsuren, gesttigt und ungesttigt, unverzweigt mit - geradzahliger C-Kette und - C-Zahl >=16 und - einer endstndigen Carboxylgruppe;9,11,13-Octadecatrienoic acid, (E,E,E)-;Ai3-22368;Einecs 208-877-3;(9E, 11E, 13E)-Octadeca-9, 11, 13-trienoic Acid;all-trans-octadeca-9,11,13-trienoic acid | | CAS: | 544-73-0 | | MF: | C18H30O2 | | MW: | 278.43 | | EINECS: | 2088773 | | Product Categories: | | | Mol File: | 544-73-0.mol |  |
| | (9E,11E,13E)-9,11,13-octadecatrienoic acid Chemical Properties |
| Melting point | 71.5°C | | Boiling point | 361.24°C (rough estimate) | | density | 0.8839 | | refractive index | 1.5000 | | storage temp. | Store at -20°C | | solubility | DMF: 30 mg/ml; DMSO: 10 mg/ml; Ethanol: 20 mg/ml | | pka | 4.78±0.10(Predicted) | | CAS DataBase Reference | 544-73-0 |
| | (9E,11E,13E)-9,11,13-octadecatrienoic acid Usage And Synthesis |
| Description | 9(E),11(E),13(E)-Octadecatrienoic acid (β-ESA) is a conjugated polyunsaturated fatty acid that is found in plant seed oils and in mixtures of conjugated linolenic acids synthesized by the alkaline isomerization of linolenic acid. It reduces growth of Caco-2 colon cancer cells in a dose-dependent and time-dependent manner. In vitro, β-ESA induces DNA fragmentation and upregulation of pro-apoptotic Bax mRNA. β-ESA decreases protein expression of the apoptosis suppression factor Bcl-2 and induces apoptosis in T24 bladder cancer cells via production of reactive oxygen species. It also inhibits bacterial fatty acid dioxygenase with a Ki value of 49 nM in vitro. | | Uses | (9E,11E,13E)-9,11,13-Octadecatrienoic Acid, is a conjugated polyunsaturated fatty acid that is found in plant seed oils and in mixtures of conjugated linolenic acids synthesized by the alkaline isomerization of linolenic acid. | | Definition | ChEBI: The all-trans isomer of 9,11,13-octadecatrienoic acid. | | IC 50 | Bcl-2 | | References | [1] YUMIKO YASUI. Growth inhibition and apoptosis induction by all-trans-conjugated linolenic acids on human colon cancer cells.[J]. Anticancer research, 2006, 26 3A: 1855-1860.
[2] ZHONGYAN SUN . Beta-eleostearic acid induce apoptosis in T24 human bladder cancer cells through reactive oxygen species (ROS)-mediated pathway[J]. Prostaglandins & other lipid mediators, 2012, 99 1: Pages 1-8. DOI: 10.1016/j.prostaglandins.2012.04.001
[3] ZAHRA MASHHADI Alan R B William E Boeglin. Robust inhibitory effects of conjugated linolenic acids on a cyclooxygenase-related linoleate 10S-dioxygenase: Comparison with COX-1 and COX-2[J]. Biochimica et biophysica acta. Molecular and cell biology of lipids, 2015, 1851 10: Pages 1346-1352. DOI: 10.1016/j.bbalip.2015.07.004 |
| | (9E,11E,13E)-9,11,13-octadecatrienoic acid Preparation Products And Raw materials |
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