1-Piperazineethanol, 4-(2-phenyl-4-quinazolinyl)-

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1-Piperazineethanol, 4-(2-phenyl-4-quinazolinyl)- manufacturers

  • BVDV-IN-1
  • BVDV-IN-1 pictures
  • $34.00
  • 2026-07-17
  • CAS:345651-04-9
  • Purity: 98.93%
  • Supply Ability: 10g
1-Piperazineethanol, 4-(2-phenyl-4-quinazolinyl)- Basic information
Product Name:1-Piperazineethanol, 4-(2-phenyl-4-quinazolinyl)-
Synonyms:1-Piperazineethanol, 4-(2-phenyl-4-quinazolinyl)-;BVDV IN-1;inhibit,virus,non-nucleoside,BVDV IN 1,activity,bovine,viral,antiviral,inhibitor,BVDVIN1,DNA/RNA Synthesis,diarrhea;2-(4-(2-Phenylquinazolin-4-yl)piperazin-1-yl)ethanol;BVDV-IN-1, 10 mM in DMSO;BVDV IN-1 ，E0942
CAS:345651-04-9
MF:C20H22N4O
MW:334.41
EINECS:
Product Categories:
Mol File:345651-04-9.mol
1-Piperazineethanol, 4-(2-phenyl-4-quinazolinyl)- Structure
1-Piperazineethanol, 4-(2-phenyl-4-quinazolinyl)- Chemical Properties
Boiling point 472.2±45.0 °C(Predicted)
density 1+-.0.06 g/cm3(Predicted)
storage temp. 4°C, protect from light
solubility DMSO : 250 mg/mL (747.59 mM; Need ultrasonic)
form Solid
pka14.96±0.10(Predicted)
color White to off-white
Safety Information
MSDS Information
1-Piperazineethanol, 4-(2-phenyl-4-quinazolinyl)- Usage And Synthesis
UsesBVDV-IN-1 is a non-nucleoside inhibitor (NNI) of bovine viral diarrhea virus (BVDV), with an EC50 of 1.8 μM. BVDV-IN-1 directly binds to a hydrophobic pocket of the BVDV RdRp. BVDV-IN-1 has antiviral activity against BVDV resistant to NNI thiosemicarbazone (TSC)[1].
Biological ActivityBVDV-IN-1 is a non-nucleoside inhibitor (NNI) of bovine viral diarrhea virus (BVDV), with an EC50 of 1.8 μM. BVDV-IN-1 directly binds to a hydrophobic pocket of the BVDV RdRp. BVDV-IN-1 has antiviral activity against BVDV resistant to NNI thiosemicarbazone (TSC)[1]. BVDV-IN-1 (compound 1.9) binds to a hydrophobic pocket of the BVDV RNA-dependent RNA polymerase (RdRp)[1].BVDV-IN-1 inhibits the replication of TSC-resistant BVDV variants in vitro[1].
References[1]. Gabriela A Fernández, et al. Design and Optimization of Quinazoline Derivatives: New Non-nucleoside Inhibitors of Bovine Viral Diarrhea Virus. Front Chem. 2020 Dec 10;8:590235.
1-Piperazineethanol, 4-(2-phenyl-4-quinazolinyl)- Preparation Products And Raw materials
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