- 3-BROMO-5-HYDROXYBENZOIC ACID
-
- $3.00 / 1KG
-
2025-09-25
- CAS:140472-69-1
- Min. Order: 1KG
- Purity: 98%
- Supply Ability: g-kg-tons, free sample is available
|
| | 3-BROMO-5-HYDROXYBENZOIC ACID Basic information |
| | 3-BROMO-5-HYDROXYBENZOIC ACID Chemical Properties |
| Melting point | 237-241 °C | | Boiling point | 388.1±32.0 °C(Predicted) | | density | 1.861±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | solubility | soluble in Methanol | | form | powder to crystal | | pka | 3.69±0.10(Predicted) | | color | White to Light yellow to Light orange | | InChI | InChI=1S/C7H5BrO3/c8-5-1-4(7(10)11)2-6(9)3-5/h1-3,9H,(H,10,11) | | InChIKey | WGIBEMRBLBGETQ-UHFFFAOYSA-N | | SMILES | C(O)(=O)C1=CC(O)=CC(Br)=C1 | | CAS DataBase Reference | 140472-69-1 |
| Hazard Codes | Xn,N | | Risk Statements | 22-50 | | Safety Statements | 61 | | RIDADR | UN 2811 6.1/PG 3 | | WGK Germany | 3 | | HazardClass | 9 | | PackingGroup | III | | HS Code | 2918290090 | | Storage Class | 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | | Hazard Classifications | Acute Tox. 3 Oral
Aquatic Acute 1 |
| | 3-BROMO-5-HYDROXYBENZOIC ACID Usage And Synthesis |
| Uses | 3-Bromo-5-hydroxybenzoic acid is a carboxylic acid derivative and is used in organic synthesis.
| | Synthesis Reference(s) | [1] Leukotriene b4 inhibitors. Patent no. US20100240678A1 | | Synthesis | To a solution of NaOH (12.2 g; 305.8 mmol) in 300 mL of water was added 3-bromo-5-iodo-benzoic acid (20 g, 61.2 mmol) and Cu2O (866 mg, 6.1 mmol). The reaction mixture was heated at 100° C. for 24 h. After complete consumption of the starting material, the reaction mixture was cooled to room temperature and filtered through celite. The filtrate was then acidified with 10% aq. HCl and extracted into ethyl acetate. The organic extract was dried over anhydrous sodium sulfate and concentrated under reduced pressure to afford the 3-Bromo-5-hydroxybenzoic acid as a tan solid (12.3 g, 93% yield). | | Purification Methods | The acid crystallises from H2O (m 238-239o), and with Me2SO4 it yields the 3-methoxy derivative with m 190-191o (from EtOH). [Baddar et al. J Chem Soc 469 1955, Beilstein 10 IV 333.] | | References | [1] Patent: US2010/240678, 2010, A1. Location in patent: Page/Page column 22
[2] Patent: WO2009/77385, 2009, A1. Location in patent: Page/Page column 63
[3] Patent: WO2005/113494, 2005, A2. Location in patent: Page/Page column 118-119 |
| | 3-BROMO-5-HYDROXYBENZOIC ACID Preparation Products And Raw materials |
|