| Company Name: |
Shanghai Merlot Chemical Co., LTD
|
| Tel: |
15821661757 |
| Email: |
226174156@qq.com |
| Products Intro: |
Product Name:1H-Benzimidazole-6-carboxylic acid, 2-[4-(4-nitrophenyl)-2-thiazolyl]hydrazide
CAS:946857-84-7
Purity:95% Package:1g；5g
|
| Company Name: |
Shanghai Yifei Biotechnology Co. , Ltd.
|
| Tel: |
021-65675885 18964387627 |
| Email: |
customer_service@efebio.com |
| Products Intro: |
Product Name:BSc3094
CAS:946857-84-7
Purity:95% Package:2mg;5mg
|
| Company Name: |
TargetMol Chemicals Inc.
|
| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:BSc3094
CAS:946857-84-7
Package:2mg/RMB 932;5mg/RMB 1810
|
1H-Benzimidazole-6-carboxylic acid, 2-[4-(4-nitrophenyl)-2-thiazolyl]hydrazide manufacturers
- BSc3094
-
- $119.00
-
2026-04-22
- CAS:946857-84-7
- Purity:
- Supply Ability: 10g
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| | 1H-Benzimidazole-6-carboxylic acid, 2-[4-(4-nitrophenyl)-2-thiazolyl]hydrazide Basic information |
| | 1H-Benzimidazole-6-carboxylic acid, 2-[4-(4-nitrophenyl)-2-thiazolyl]hydrazide Chemical Properties |
| density | 1.567±0.06 g/cm3(Predicted) | | storage temp. | 4°C, protect from light | | form | Solid | | pka | 9.16±0.43(Predicted) | | color | Yellow to orange |
| | 1H-Benzimidazole-6-carboxylic acid, 2-[4-(4-nitrophenyl)-2-thiazolyl]hydrazide Usage And Synthesis |
| Uses | BSc3094 is a Tau aggregation inhibitor. BSc3094 can be used for the research of Alzheimer's disease (AD)[1]. | | Biological Activity | BSc3094 is a Tau aggregation inhibitor. BSc3094 can be used for the research of Alzheimer’s disease (AD)[1].
BSc3094 (3 mg/kg; i.v.) direct intraventricular administration reduces sarkosyl-insoluble Tau[1].BSc3094 (0.075~1.5 mM; intraventricular administration) reduces the levels of sarkosyl-insoluble Tau in cortical extracts by ≈70%[1].BSc3094 reverses the pre-synaptic impairment in organotypic hippocampal slices from pro-aggregant mice, by reversing the pairedpulse depression observed in non-treated pro-aggregant Tau slices after applying a paired-pulse stimulus of the Schaffer collaterals. BSc3094 reverses the increase in Tau phosphorylation levels in rTg4510 mice down to control level. BSc3094 partially reversed the memory deficits in rTg4510 mice[1]. | | in vivo | BSc3094 (3 mg/kg; i.v.) direct intraventricular administration reduces sarkosyl-insoluble Tau[1].
BSc3094 (0.075~1.5 mM; intraventricular administration) reduces the levels of sarkosyl-insoluble Tau in cortical extracts by ≈70%[1].
BSc3094 reverses the pre-synaptic impairment in organotypic hippocampal slices from pro-aggregant mice, by reversing the pairedpulse depression observed in non-treated pro-aggregant Tau slices after applying a paired-pulse stimulus of the Schaffer collaterals. BSc3094 reverses the increase in Tau phosphorylation levels in rTg4510 mice down to control level. BSc3094 partially reversed the memory deficits in rTg4510 mice[1]. | Animal Model: | Mice[1] | | Dosage: | 3 mg/kg | | Administration: | I.v. | | Result: | Direct intraventricular administration reduced sarkosyl-insoluble Tau.
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| Animal Model: | rTg4510 mice[1] | | Dosage: | 0.075~1.5 mM | | Administration: | Intraventricular administration | | Result: | Reduced the levels of sarkosyl-insoluble Tau in cortical extracts by ≈70%.
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| | References | [1]. Anglada-Huguet M, et al. Inhibition of Tau aggregation with BSc3094 reduces Tau and decreases cognitive deficits in rTg4510 mice. Alzheimers Dement (N Y). 2021;7(1):e12170. Published 2021 Jun 1. |
| | 1H-Benzimidazole-6-carboxylic acid, 2-[4-(4-nitrophenyl)-2-thiazolyl]hydrazide Preparation Products And Raw materials |
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