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| | Morphinan-6-one, 4,5-epoxy-14-hydroxy-3-(methoxy-d3)-, hydrochloride (1:1), (5α)- Basic information |
| | Morphinan-6-one, 4,5-epoxy-14-hydroxy-3-(methoxy-d3)-, hydrochloride (1:1), (5α)- Chemical Properties |
| | Morphinan-6-one, 4,5-epoxy-14-hydroxy-3-(methoxy-d3)-, hydrochloride (1:1), (5α)- Usage And Synthesis |
| Description | Noroxycodone-d3 (hydrochloride) (CRM) is intended for use as an internal standard for the quantification of noroxycodone by GC- or LC-MS. Noroxycodone is categorized as an opioid.1,2 Noroxycodone is a metabolite of oxycodone .3,4 This product is intended for research and forensic applications. | | References | 1. Leow, K.P., and Smith, M.T. The antinociceptive potencies of oxycodone, noroxycodone and morphine after intracerebroventricular administration to rats Life Sci. 54(17),1229-1236(1994).
2. Lalovic, B., Kharasch, E., Hoffer, C., et al. Pharmacokinetics and pharmacodynamics of oral oxycodone in healthy human subjects: Role of circulating active metabolites Clin. Pharmacol. Ther. 79(5),461-479(2006).
3. Romand, S., Spaggiari, D., Marsousi, N., et al. Characterization of oxycodone in vitro metabolism by human cytochromes P450 and UDP-glucuronosyltransferases J. Pharm. Biomed. Anal. 144,129-137(2017).
4. Fang, W.B., Lofwall, M.R., Walsh, S.L., et al. Determination of oxycodone, noroxycodone and oxymorphone by high-performance liquid chromatography-electrospray ionization-tandem mass spectrometry in human matrices: In vivo and in vitro applications J. Anal. Toxicol. 37(6),337-344(2013). |
| | Morphinan-6-one, 4,5-epoxy-14-hydroxy-3-(methoxy-d3)-, hydrochloride (1:1), (5α)- Preparation Products And Raw materials |
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