(32-Carbonyl)-RMC-5552

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Company Name: Shanghai Lollane Biological Technology Co.,Ltd.  
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(32-Carbonyl)-RMC-5552 Basic information
Product Name:(32-Carbonyl)-RMC-5552
Synonyms:(32-Carbonyl)-RMC-5552
CAS:2382768-55-8
MF:C93H134N10O24
MW:1776.11
EINECS:
Product Categories:
Mol File:Mol File
(32-Carbonyl)-RMC-5552 Structure
(32-Carbonyl)-RMC-5552 Chemical Properties
density 1.31±0.1 g/cm3(Predicted)
storage temp. 4°C, away from moisture
solubility DMSO : 146.67 mg/mL (82.58 mM; Need ultrasonic)
form Solid
pka10.40±0.70(Predicted)
color White to off-white
Safety Information
MSDS Information
(32-Carbonyl)-RMC-5552 Usage And Synthesis
Uses(32-Carbonyl)-RMC-5552 is a potent mTOR inhibitor. (32-Carbonyl)-RMC-5552 inhibits mTORC1 and mTORC2 substrate (p-P70S6K-(T389), p-4E-BP1-(T37/36), AND p-AKT1/2/3-(S473)) phosphorylation with pIC50s of > 9, >9 and between 8 and 9, respectively (patent WO2019212990A1, example 2)[1].
Biological Activity(32-Carbonyl)-RMC-5552 is a potent mTOR inhibitor. (32-Carbonyl)-RMC-5552 inhibits mTORC1 and mTORC2 substrate (p-P70S6K-(T389), p-4E-BP1-(T37/36), AND p-AKT1/2/3-(S473)) phosphorylation with pIC50s of > 9, >9 and between 8 and 9, respectively (patent WO2019212990A1, example 2)[1].
References[1]. Jennifer PITZEN, et al. C40-, c28-, and c-32-linked rapamycin analogs as mtor inhibitors. WO2019212990A1.
(32-Carbonyl)-RMC-5552 Preparation Products And Raw materials
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