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| | (3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride Basic information |
| Product Name: | (3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride | | Synonyms: | CIS-N-BENZYL-3-METHYLAMINO-4-METHYL-PIPERIDINE BIS-(HYDROCHLORIDE);cis-1-Benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride;cis-1-Benzyl-4-methyl-3-(methylamino)piperidine dihydrochloride 95+%;cis-1-Benzyl-N3,4-dimethylpiperidin-3-amine dihydrochloride;(3R,4R)-1-BENZYL-N,4-DIMETHYLPIPERIDIN-3-AMINE DIHYDROCHLORIDE;(3R,4R)-1-benzyl-N,4-diMethylpiperidin-3-aMine BIS-(HYDROCHLORIDE);3-PiperidinaMine, N,4-diMethyl-1-(phenylMethyl)-, hydrochloride (1:2), (3R,4R)-;(3R,4R)-N,4-DiMethyl-1-(phenylMethyl)-3-piperidi | | CAS: | 1062580-52-2 | | MF: | C14H23ClN2 | | MW: | 254.8 | | EINECS: | 229-486-4 | | Product Categories: | 1 | | Mol File: | Mol File |  |
| | (3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride Chemical Properties |
| Melting point | 249～251℃ | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | solubility | Aqueous Acid (Slightly), DMSO (Slightly, Heated, Sonicated), Methanol (Slightly) | | form | Solid | | color | White to Off-White | | InChI | InChI=1/C14H22N2.ClH/c1-12-8-9-16(11-14(12)15-2)10-13-6-4-3-5-7-13;/h3-7,12,14-15H,8-11H2,1-2H3;1H/t12-,14+;/s3 | | InChIKey | FVRZQLQXDPJADE-WLZBWWFYNA-N | | SMILES | C(C1C=CC=CC=1)N1CC[C@@H](C)[C@@H](NC)C1.Cl |&1:10,12,r| |
| HazardClass | IRRITANT | | HS Code | 2933399990 |
| | (3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride Usage And Synthesis |
| Uses | (3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride can be used as organic synthesis intermediates and pharmaceutical intermediates, mainly used in laboratory research and development processes and chemical production processes. | | Uses | (3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride is a related compound of Tofacitinib (T528000). (3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride can be used to prepare janus kinase 1 selective inhibitor. | | Application | (3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride is an organic synthesis intermediate and a pharmaceutical intermediate. In laboratory research and in chemical and pharmaceutical development, it is primarily used as an intermediate for the active pharmaceutical ingredient tofacitinib. Tofacitinib is used to treat adult patients with moderate to severe rheumatoid arthritis who have an inadequate response to or are intolerant of methotrexate. | | Synthesis | 
TiCl4(0.2g, 1mmol) and NEt3(0.15 g, 1.5 mmol) were added to toluene, and then add 1-benzyl-4-methyl-3-ketone piperidine (20.3 g, 100 mmol) at 35 ℃. The methylamine solution is added to the reaction solution (9.32 g, 120 mmol) and reaction for 4 h, followed by adding NaBH (OAC) 3 (0.32 g, 1.5 mmol) and glacial acetic acid 2 ml. After the reaction is complete, add saturated salt water to wash the reaction mixture. (3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride was obtained after further purification. |
| | (3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride Preparation Products And Raw materials |
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