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| | 2-amino-4-chlorobenzamide Basic information | | Uses |
| Product Name: | 2-amino-4-chlorobenzamide | | Synonyms: | 2-amino-4-chlorobenzamide;2-amino-4-chlorobenzamide(SALTDATA: FREE);2-aMino-4-chlrobenzaMide;4-Chloroanthranilamide;2-amino-4-chlorophenylformamide;Benzamide, 2-amino-4-chloro- | | CAS: | 5900-59-4 | | MF: | C7H7ClN2O | | MW: | 170.6 | | EINECS: | 200-002-4 | | Product Categories: | | | Mol File: | 5900-59-4.mol |  |
| | 2-amino-4-chlorobenzamide Chemical Properties |
| Melting point | 181.5 °C | | Boiling point | 308.8±27.0 °C(Predicted) | | density | 1.394±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | pka | 15.48±0.50(Predicted) | | form | solid | | Appearance | Off-white to light yellow Solid | | InChI | 1S/C7H7ClN2O/c8-4-1-2-5(7(10)11)6(9)3-4/h1-3H,9H2,(H2,10,11) | | InChIKey | QNEJYHVIYJFNHC-UHFFFAOYSA-N | | SMILES | O=C(N)C(C(N)=C1)=CC=C1Cl |
| Risk Statements | 43 | | Safety Statements | 36/37 | | WGK Germany | WGK 3 | | HS Code | 2924297099 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Acute Tox. 4 Oral
Eye Irrit. 2
Skin Sens. 1 |
| | 2-amino-4-chlorobenzamide Usage And Synthesis |
| Uses | 2-Amino-4-chlorobenzamide is a useful research chemical. | | Synthesis | Method I: Synthesis of 2-amino-4-chlorobenzamide (ii-b)
1. 2-Amino-4-chlorobenzoic acid (3.42 g, 20 mmol) was dissolved in DMF (45 mL) and HOBt (2.70 g, 20 mmol) was added.
2. After stirring for 10 min, EDC-HCl (3.82 g, 20 mmol) was added to the mixture.
3. the reaction mixture was stirred at room temperature for 2 hr.
4. NH4OH (28%, 5 mL) was slowly added at 0 °C with vigorous stirring.
5. After addition, continue stirring at room temperature for 2 hours.
6. The reaction mixture was added slowly dropwise to water (200 mL) and a precipitate was precipitated.
7. The precipitate was collected by filtration and dried under vacuum to give 2.98 g of the target product ii-b as a gray solid in 87.6% yield. 8.
8. The product was characterized by LCMS m/z = 171.0 (M + 1), 173.0 (M + 3) (Method B) (retention time = 1.39 min).
1H NMR (400 MHz, DMSO-d6): δ 7.27 (d, J = 9.6 Hz, 1H), 6.68 (d, J = 2.4 Hz, 1H), 6.60 (dd, J = 8.4, 2.0 Hz, 1H), 5.50-5.82 (m, 4H). | | References | [1] European Journal of Medicinal Chemistry, 2018, vol. 157, p. 1361 - 1375
[2] Patent: US2015/307477, 2015, A1. Location in patent: Paragraph 1473
[3] Patent: JP6121658, 2017, B2. Location in patent: Paragraph 1063; 1064; 1065
[4] Patent: WO2010/99379, 2010, A1. Location in patent: Page/Page column 142
[5] Arkivoc, 2012, vol. 2012, # 8, p. 198 - 213 |
| | 2-amino-4-chlorobenzamide Preparation Products And Raw materials |
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