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| | 3-ACETOXY-5-BROMOINDOLE Basic information |
| | 3-ACETOXY-5-BROMOINDOLE Chemical Properties |
| Melting point | 130-132 °C(lit.) | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | solubility | ethanol: soluble50mg/mL, clear, colorless | | form | powder to crystal | | color | White to Purple | | BRN | 168698 | | InChI | 1S/C10H8BrNO2/c1-6(13)14-10-5-12-9-3-2-7(11)4-8(9)10/h2-5,12H,1H3 | | InChIKey | KFTGECHXNQBTNZ-UHFFFAOYSA-N | | SMILES | CC(=O)Oc1c[nH]c2ccc(Br)cc12 | | CAS DataBase Reference | 17357-14-1(CAS DataBase Reference) | | EPA Substance Registry System | 1H-Indol-3-ol, 5-bromo-, acetate (ester) (17357-14-1) |
| Safety Statements | 22-24/25 | | WGK Germany | 3 | | F | 8-10 | | TSCA | TSCA listed | | HS Code | 2933998090 | | Storage Class | 11 - Combustible Solids |
| | 3-ACETOXY-5-BROMOINDOLE Usage And Synthesis |
| Uses | 5-Bromoindoxyl acetate may be used:
- as esterase substrate to investigate the activity of non-specific esterase in the matrix of developing bovine enamel
- in histochemical studies of the nonspecific esterase of mouse epididymis
- as substrate to investigate the esterase activity in guinea-pig thyroid and mouse epididymis epithelial cells
- in staining procedure for the frozen sections of muscle fixed in buffered formaldehyde
| | General Description | 5-Bromoindoxyl acetate is a halogenated heterocyclic compound. It is widely used as esterase substrate. | | Synthesis | Method I. The 3-hydroxyindole acetate, N-bromosuccinimide and 150 mL of carbon tetrachloride. It was added into 250 mL round bottom flask and refluxed in oil bath for 2 h. The reaction process was monitored by TLC. At the completion of the reaction, the solution changed from dark yellow to light yellow and a white solid (succinimide) was precipitated. The filtrate was withdrawn and washed, and the filtrate was collected and evaporated to obtain 5-bromo-3-hydroxyindole acetate. Method II. In a 500 mL single-necked flask, 3-hydroxyindole acetic acid ester was dissolved in tetrahydrofuran solution, N-bromosuccinimide was added in an ice bath, and the reaction was stirred at 0??C for 3 h. The reaction was completed. The reaction mixture was poured into 150 mL of ice water and extracted with methyl tert-butyl ether (100 mL??4), the organic phases were combined, dried with anhydrous sodium sulfate, and concentrated to obtain 5-bromo-3-hydroxyindole acetate. |
| | 3-ACETOXY-5-BROMOINDOLE Preparation Products And Raw materials |
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