| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:AZ12253801
CAS:851432-37-6
Package:100mg/RMB 17500;25mg/RMB 10600;50mg/RMB 13800
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4-Pyrimidinamine, 6-methyl-N-(5-methyl-1H-pyrazol-3-yl)-2-[(2S)-2-[3-(2-pyridinyl)-5-isoxazolyl]-1-pyrrolidinyl]- manufacturers
- AZ12253801
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- $2500.00
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2026-04-21
- CAS:851432-37-6
- Purity:
- Supply Ability: 10g
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| | 4-Pyrimidinamine, 6-methyl-N-(5-methyl-1H-pyrazol-3-yl)-2-[(2S)-2-[3-(2-pyridinyl)-5-isoxazolyl]-1-pyrrolidinyl]- Basic information |
| | 4-Pyrimidinamine, 6-methyl-N-(5-methyl-1H-pyrazol-3-yl)-2-[(2S)-2-[3-(2-pyridinyl)-5-isoxazolyl]-1-pyrrolidinyl]- Chemical Properties |
| Boiling point | 729.8±70.0 °C(Predicted) | | density | 1.344±0.06 g/cm3(Predicted) | | pka | 14.25±0.10(Predicted) |
| | 4-Pyrimidinamine, 6-methyl-N-(5-methyl-1H-pyrazol-3-yl)-2-[(2S)-2-[3-(2-pyridinyl)-5-isoxazolyl]-1-pyrrolidinyl]- Usage And Synthesis |
| Description | AZ12253801 is an inhibitor of the type 1 insulin-like growth factor receptor (IGF-1R). | | Uses | AZ12253801 is an ATP-competitive IGF-1R tyrosine kinase inhibitor that shows ～10-fold selectivity over the insulin receptor. AZ12253801 inhibits IGF-1R–driven proliferation in 3T3 mouse fibroblasts (transfected with human IGF-1R) with an IC50 of 17 nmol/L. The IC50for epidermal growth factor receptor (EGFR)–driven proliferation is 440 nmol/L. Anti-tumor activity. | | References | [1] https://aacrjournals.org/cancerres/article/70/16/6412/559448/Type-1-Insulin-like-Growth-Factor-Receptor |
| | 4-Pyrimidinamine, 6-methyl-N-(5-methyl-1H-pyrazol-3-yl)-2-[(2S)-2-[3-(2-pyridinyl)-5-isoxazolyl]-1-pyrrolidinyl]- Preparation Products And Raw materials |
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