| Company Name: |
ShangHai Caerulum Pharma Discovery Co., Ltd.
|
| Tel: |
18149758185 |
| Email: |
sales-cpd@caerulumpharma.com |
| Products Intro: |
Product Name:Benzamide, N-hydroxy-4-(6-hydroxy-4-oxo-8-tricyclo[3.3.1.13,7]dec-1-yl-4H-1-benzopyran-2-yl)-
CAS:2055829-03-1
Purity:98% Package:1g;10g;100g
|
| Company Name: |
TargetMol Chemicals Inc.
|
| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:Nur77 modulator 2
CAS:2055829-03-1
Package:100mg/RMB 17500;25mg/RMB 10600;50mg/RMB 13800
|
Benzamide, N-hydroxy-4-(6-hydroxy-4-oxo-8-tricyclo[3.3.1.13,7]dec-1-yl-4H-1-benzopyran-2-yl)- manufacturers
- Nur77 modulator 2
-
- $2500.00 / 100mg
-
2025-10-27
- CAS:2055829-03-1
- Min. Order:
- Purity:
- Supply Ability: 10g
|
| | Benzamide, N-hydroxy-4-(6-hydroxy-4-oxo-8-tricyclo[3.3.1.13,7]dec-1-yl-4H-1-benzopyran-2-yl)- Basic information |
| | Benzamide, N-hydroxy-4-(6-hydroxy-4-oxo-8-tricyclo[3.3.1.13,7]dec-1-yl-4H-1-benzopyran-2-yl)- Chemical Properties |
| density | 1.400±0.06 g/cm3(Predicted) | | pka | 9.02±0.40(Predicted) |
| | Benzamide, N-hydroxy-4-(6-hydroxy-4-oxo-8-tricyclo[3.3.1.13,7]dec-1-yl-4H-1-benzopyran-2-yl)- Usage And Synthesis |
| Uses | Nur77 modulator 2, a Nur77 modulator (Kd of 0.35 μM), is a potent and orally active inflammation inhibitor. Nur77 modulator 2 modulates the colocalization of Nur77 at mitochondria[1]. | | in vivo | Nur77 modulator 2 (Compound B7; 5-10 mg/kg; p.o; for 1 week) shows in vivo anti-inflammatory activity in the LPS-induced mice model of acute lung injury (ALI)[1]. | | IC 50 | Nur77/NR4A1 | | References | [1] Mingtao Ao, et al. Design and synthesis of adamantyl-substituted flavonoid derivatives as anti-inflammatory Nur77 modulators: Compound B7 targets Nur77 and improves LPS-induced inflammation in vitro and in vivo. Bioorg Chem. 2022 Jan 29;120:105645. DOI:10.1016/j.bioorg.2022.105645 |
| | Benzamide, N-hydroxy-4-(6-hydroxy-4-oxo-8-tricyclo[3.3.1.13,7]dec-1-yl-4H-1-benzopyran-2-yl)- Preparation Products And Raw materials |
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