|
|
| | 2-Aminooxyethylamine dihydrochloride Basic information |
| Product Name: | 2-Aminooxyethylamine dihydrochloride | | Synonyms: | 2-AMinoethoxyaMine Dihydrochloride;2-(AMinooxy)ethanaMine dihydrochloride;O-(2-AMinoethyl)hydroxylaMine Dihydrochloride;EthanaMine, 2-(aMinooxy)- (dihydrochloride);O-(2-aminoethyl)hydroxylamine;2-(AMINOOXY)ETHYLAMINE 2HCL;2-(O-aminooxy)ethylamine dihydrochloride;2-(Aminooxy)-1-ethanamine DiHCl | | CAS: | 37866-45-8 | | MF: | C2H10Cl2N2O | | MW: | 149.0196 | | EINECS: | 412-310-7 | | Product Categories: | Aliphatics;Amines | | Mol File: | 37866-45-8.mol |  |
| | 2-Aminooxyethylamine dihydrochloride Chemical Properties |
| Melting point | 205-207° | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | solubility | DMSO (Slightly), Methanol (Slightly) | | form | Solid | | color | White to Off-White | | Stability: | Hygroscopic |
| | 2-Aminooxyethylamine dihydrochloride Usage And Synthesis |
| Chemical Properties | White Solid | | Uses | 2-AMinoethoxyaMine Dihydrochloride is used in the preparation of istaroxime analogs. | | Synthesis | General procedure for the synthesis of 2-aminoethoxyamine dihydrochloride from benzamide,N-(2-aminoethoxy)-:
1. reagents and reaction conditions: HCl was used as reagent and reaction conditions were reflux.
2. M-10 (1.0 g) and 15 mL of aqueous 6 mol/L hydrochloric acid were added to the reaction vessel.
3. Heat and reflux for 4 hours.
4. Upon completion of the reaction, the reaction mixture was cooled.
5. Remove the precipitate by filtration.
6. The filtrate was evaporated to dryness to obtain the crude product.
7. The crude product was recrystallized using methanol. 8.
8. 0.61 g of yellow crystals, i.e. M-11, were obtained in 74% yield. | | References | [1] Patent: CN105585607, 2016, A. Location in patent: Paragraph 0131; 0132; 0133; 0134; 0135; 0136; 0137
[2] Russian Journal of General Chemistry, 2017, vol. 87, # 11, p. 2643 - 2647 |
| | 2-Aminooxyethylamine dihydrochloride Preparation Products And Raw materials |
|