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TM608

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TM608 Suppliers list
Company Name: TargetMol Chemicals Inc.
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Email: support@targetmol.com
Products Intro: Product Name:TM608；TM 608;TM-608
CAS:1956343-52-4
Package:100 mg；500 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
TM608 Basic information
Product Name:TM608
Synonyms:TM 608;TM608;TM-608
CAS:1956343-52-4
MF:C43H37BrCl2N3O4PS
MW:873.62
EINECS:
Product Categories:
Mol File:1956343-52-4.mol
TM608 Structure
TM608 Chemical Properties
Safety Information
MSDS Information
TM608 Usage And Synthesis
DescriptionTM608 is a potent and selectiv c-MET inhibitor which targets Mitochondrial and Kills Erlotinib-Resistant Lung Cancer Cells. TM608 is the first TPP-TKI conjugate, can rapidly accumulates in mitochondria and suppresses the activation of MET in high MET expressing, erlotinib-resistant HCC827B cells (total cell lysates and mitochondrial fractions). TM608 was as potent and apoptogenic as PHA665752 in abrogating NSCLC cell viability. Directed accessibility to the mitochondria as afforded by a targeting moiety like TPP could conceivably compensate for deficient activity if uptake is rapid, cumulative, and selective.
TM608 Preparation Products And Raw materials
Tag:TM608(1956343-52-4) Related Product Information
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