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| | 4-(2-Bromo-acetyl)-benzoic acid Basic information |
| | 4-(2-Bromo-acetyl)-benzoic acid Chemical Properties |
| Melting point | 224-225℃ (methanol ) | | Boiling point | 386.2±22.0 °C(Predicted) | | density | 1.657±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | pka | 3.68±0.10(Predicted) | | form | solid | | color | Off-white |
| RIDADR | 1759 | | HazardClass | 8 | | PackingGroup | Ⅲ | | HS Code | 2918290090 |
| | 4-(2-Bromo-acetyl)-benzoic acid Usage And Synthesis |
| Uses | A phenacyl bromide | | Synthesis | General procedure for the synthesis of 4-(2-bromoacetyl)benzoic acid from 4-acetylbenzoic acid: 1 mmol of 4-acetylbenzoic acid was dissolved in 10 mL of acetic acid (AcOH). Subsequently, 1 equivalent of bromine was dissolved in 10 mL of acetic acid (AcOH) and added dropwise to the reaction mixture. The reaction mixture was stirred at room temperature for 4 hours. After completion of the reaction, the solvent was evaporated to dryness. The product was purified by normal phase column chromatography using a gradient increasing dichloromethane solution of methanol as eluent. | | References | [1] Journal of the American Chemical Society, 2000, vol. 122, # 39, p. 9361 - 9366
[2] European Journal of Medicinal Chemistry, 2014, vol. 77, p. 361 - 377
[3] Russian Journal of Applied Chemistry, 2007, vol. 80, # 4, p. 571 - 575
[4] Bioorganic and Medicinal Chemistry, 1997, vol. 5, # 3, p. 601 - 621
[5] Journal of Medicinal Chemistry, 2005, vol. 48, # 24, p. 7520 - 7534 |
| | 4-(2-Bromo-acetyl)-benzoic acid Preparation Products And Raw materials |
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