拉氟莫司
| 中文名称 | 拉氟莫司 |
|---|---|
| 中文同义词 | 拉氟莫司;化合物 T11813;13C3,15N]-拉氟尼司;化合物 LAFLUNIMUS;AP-0325;AP-325;HR-325 |
| 英文名称 | Laflunimus |
| 英文同义词 | LCBOKWGFIPORJD-QBFSEMIESA-N;Laflunimus;2-Propenamide, 2-cyano-3-cyclopropyl-3-hydroxy-N-[3-methyl-4-(trifluoromethyl)phenyl]-, (2Z)-;AP-325;AP-0325 |
| CAS号 | 147076-36-6 |
| 分子式 | C15H13F3N2O2 |
| 分子量 | 310.274 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 147076-36-6.mol |
| 结构式 |  |
拉氟莫司 性质
| 储存条件 | Store at -20°C |
|---|---|
| 溶解度 | 溶于二甲基亚砜 |
| 形态 | 固体 |
| 颜色 | 黄至卡其色 |
Ig secretion from mouse splenocytes was induced by lipopolysaccharide (LPS) for 5 days. Laflunimus inhibited the secretion of IgM and IgG with IC
50
values of 2.5 and 2 µM , respectively. Adding Uridine (50 µ M) increased these values to 70 and 60 µ M, respectively. Laflunimus inhibits LPS-induced kappa light-chain cell surface expression on 70Z/3 cells, a property also reversed by uridine.
Laflunimus (HR325) is more potent than A77 1726 as an inhibitor of PGHS in guinea pig polymorphonuclear leukocytes (IC
50
= 415 and 4400 nM, respectively) and on isolated ovine PGHS-1 (IC
50
=64 and 742 µM) and PGHS-2 (IC
50
=100 and 2766 µM).
HR325 (50 mg/kg; p.o.; days 14-18 after being injected with SRBC) inhibits the secondary anti-sheep red blood cell (SRBC) antibody response with ID 50 values of 38 mg/kg.
| Animal Model: | Male CD-1 mice (20-24 g) |
| Dosage: | 50 mg/kg |
| Administration: | Oral; days 14-18 after being injected with SRBC |
| Result: | The level of circulating anti-SRBC IgG in this model was inhibited dose relatedly by orally administered HR325. |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2025/12/22 | HY-101813 | 拉氟莫司 Laflunimus | 147076-36-6 | 1 mg | 1363元 |
| 2025/12/22 | HY-101813 | 拉氟莫司 Laflunimus | 147076-36-6 | 5mg | 3000元 |